ID   DPM2_SCHPO              Reviewed;          72 AA.
AC   Q9USW6;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Dolichol phosphate-mannose biosynthesis regulatory protein;
GN   Name=dpm2; ORFNames=SPBC21B10.11;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Regulates the biosynthesis of dolichol phosphate-mannose.
CC       Essential for the ER localization and stable expression of dpm1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Composed of three subunits; dpm1, dpm2 and dpm3.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DPM2 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAB57919.1; -; Genomic_DNA.
DR   PIR; T39916; T39916.
DR   RefSeq; NP_595676.1; NM_001021571.2.
DR   AlphaFoldDB; Q9USW6; -.
DR   BioGRID; 277231; 2.
DR   STRING; 4896.SPBC21B10.11.1; -.
DR   PaxDb; Q9USW6; -.
DR   EnsemblFungi; SPBC21B10.11.1; SPBC21B10.11.1:pep; SPBC21B10.11.
DR   GeneID; 2540708; -.
DR   KEGG; spo:SPBC21B10.11; -.
DR   PomBase; SPBC21B10.11; dpm2.
DR   VEuPathDB; FungiDB:SPBC21B10.11; -.
DR   eggNOG; KOG3488; Eukaryota.
DR   HOGENOM; CLU_150144_2_1_1; -.
DR   InParanoid; Q9USW6; -.
DR   OMA; WTLFMPF; -.
DR   PhylomeDB; Q9USW6; -.
DR   Reactome; R-SPO-162699; Synthesis of dolichyl-phosphate mannose.
DR   Reactome; R-SPO-162710; Synthesis of glycosylphosphatidylinositol (GPI).
DR   PRO; PR:Q9USW6; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR   GO; GO:0033185; C:dolichol-phosphate-mannose synthase complex; ISO:PomBase.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0030234; F:enzyme regulator activity; IBA:GO_Central.
DR   GO; GO:0019348; P:dolichol metabolic process; IEA:InterPro.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006487; P:protein N-linked glycosylation; IC:PomBase.
DR   GO; GO:0006493; P:protein O-linked glycosylation; IC:PomBase.
DR   InterPro; IPR009914; DPM2.
DR   PANTHER; PTHR15039; PTHR15039; 1.
DR   Pfam; PF07297; DPM2; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..72
FT                   /note="Dolichol phosphate-mannose biosynthesis regulatory
FT                   protein"
FT                   /id="PRO_0000220876"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   72 AA;  8267 MW;  0038A5BBB1022234 CRC64;
     MIVYISTAAF LYYTIWVLIM PFVDNMNISQ KLFLDREWAI TIPVAVMLFG ICLIGTFVSL
     LMIKSSKKKS DL