ID   DPM3_BOVIN              Reviewed;          92 AA.
AC   Q3ZC71;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Dolichol-phosphate mannosyltransferase subunit 3;
DE   AltName: Full=Dolichol-phosphate mannose synthase subunit 3;
DE            Short=DPM synthase subunit 3;
DE   AltName: Full=Dolichyl-phosphate beta-D-mannosyltransferase subunit 3;
DE   AltName: Full=Mannose-P-dolichol synthase subunit 3;
DE            Short=MPD synthase subunit 3;
GN   Name=DPM3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stabilizer subunit of the dolichol-phosphate mannose (DPM)
CC       synthase complex; tethers catalytic subunit DPM1 to the endoplasmic
CC       reticulum. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBUNIT: Component of the dolichol-phosphate mannose (DPM) synthase
CC       complex composed of DPM1, DPM2 and DPM3; within the complex, associates
CC       with DPM1 via its C-terminal domain and with DPM2 via its N-terminal
CC       portion. This interaction stabilizes DPM1 protein.
CC       {ECO:0000250|UniProtKB:Q9P2X0}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DPM3 family. {ECO:0000305}.
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DR   EMBL; BC102881; AAI02882.1; -; mRNA.
DR   RefSeq; NP_001029532.1; NM_001034360.1.
DR   AlphaFoldDB; Q3ZC71; -.
DR   SMR; Q3ZC71; -.
DR   STRING; 9913.ENSBTAP00000004597; -.
DR   PaxDb; Q3ZC71; -.
DR   PRIDE; Q3ZC71; -.
DR   Ensembl; ENSBTAT00000004597; ENSBTAP00000004597; ENSBTAG00000003535.
DR   GeneID; 509745; -.
DR   KEGG; bta:509745; -.
DR   CTD; 54344; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003535; -.
DR   VGNC; VGNC:28185; DPM3.
DR   eggNOG; KOG4841; Eukaryota.
DR   GeneTree; ENSGT00390000008892; -.
DR   HOGENOM; CLU_150782_0_1_1; -.
DR   InParanoid; Q3ZC71; -.
DR   OMA; MTKLMQW; -.
DR   OrthoDB; 1612544at2759; -.
DR   TreeFam; TF300274; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000003535; Expressed in ileocecal valve and 113 other tissues.
DR   GO; GO:0033185; C:dolichol-phosphate-mannose synthase complex; IBA:GO_Central.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:Ensembl.
DR   GO; GO:0019348; P:dolichol metabolic process; IEA:Ensembl.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR   InterPro; IPR013174; DPM3.
DR   PANTHER; PTHR16433; PTHR16433; 1.
DR   Pfam; PF08285; DPM3; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..92
FT                   /note="Dolichol-phosphate mannosyltransferase subunit 3"
FT                   /id="PRO_0000328450"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   92 AA;  10142 MW;  88F5B36D9B44C7D7 CRC64;
     MTKLAQWLWA LALLGSTWAA LTMGALGLEL PSSCREVLWP LPAYLLVSAG CYALGTVGYR
     VATFHDCEDA ARELQSQIQE ARADLTRRGL RF