ID   DPM3_DICDI              Reviewed;          92 AA.
AC   Q76NT6; Q54ZL4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Dolichol-phosphate mannosyltransferase subunit 3;
DE   AltName: Full=Dolichol-phosphate mannose synthase subunit 3;
DE            Short=DPM synthase subunit 3;
DE   AltName: Full=Dolichyl-phosphate beta-D-mannosyltransferase subunit 3;
DE   AltName: Full=Mannose-P-dolichol synthase subunit 3;
DE            Short=MPD synthase subunit 3;
GN   Name=dpm3; ORFNames=DDB_G0277435;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Stabilizer subunit of the dolichol-phosphate mannose (DPM)
CC       synthase complex; tethers catalytic subunit dpm1 to the ER.
CC       {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBUNIT: Component of the dolichol-phosphate mannose (DPM) synthase
CC       complex composed of dpm1, dpm2 and dpm3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DPM3 family. {ECO:0000305}.
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DR   EMBL; AAFI02000020; EAL68680.1; -; Genomic_DNA.
DR   RefSeq; XP_642628.1; XM_637536.1.
DR   AlphaFoldDB; Q76NT6; -.
DR   STRING; 44689.DDB0266960; -.
DR   PaxDb; Q76NT6; -.
DR   EnsemblProtists; EAL68680; EAL68680; DDB_G0277435.
DR   GeneID; 8621045; -.
DR   KEGG; ddi:DDB_G0277435; -.
DR   dictyBase; DDB_G0277435; dpm3.
DR   eggNOG; ENOG502SBV9; Eukaryota.
DR   HOGENOM; CLU_150782_1_1_1; -.
DR   InParanoid; Q76NT6; -.
DR   OMA; MTKLMQW; -.
DR   PhylomeDB; Q76NT6; -.
DR   Reactome; R-DDI-162699; Synthesis of dolichyl-phosphate mannose.
DR   UniPathway; UPA00378; -.
DR   PRO; PR:Q76NT6; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0033185; C:dolichol-phosphate-mannose synthase complex; IBA:GO_Central.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR013174; DPM3.
DR   PANTHER; PTHR16433; PTHR16433; 1.
DR   Pfam; PF08285; DPM3; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..92
FT                   /note="Dolichol-phosphate mannosyltransferase subunit 3"
FT                   /id="PRO_0000328452"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   92 AA;  10577 MW;  1B87F5698210162F CRC64;
     MKRYQKVFIT FTFLMTFWLL LVLEKIQLNL SPSIQSIIPF LPLYAVVCFG SYSLGVIAYN
     LLIMSDCKEA SESLFDEIKE AKESLRAKGM KL