ID   ADEC_CLOAB              Reviewed;         570 AA.
AC   Q97KN0;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=CA_C0887;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; AE001437; AAK78863.1; -; Genomic_DNA.
DR   PIR; D97009; D97009.
DR   RefSeq; NP_347523.1; NC_003030.1.
DR   RefSeq; WP_010964205.1; NC_003030.1.
DR   AlphaFoldDB; Q97KN0; -.
DR   SMR; Q97KN0; -.
DR   STRING; 272562.CA_C0887; -.
DR   PRIDE; Q97KN0; -.
DR   EnsemblBacteria; AAK78863; AAK78863; CA_C0887.
DR   GeneID; 44997398; -.
DR   KEGG; cac:CA_C0887; -.
DR   PATRIC; fig|272562.8.peg.1097; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; EHECSTV; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..570
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000142412"
SQ   SEQUENCE   570 AA;  62622 MW;  B0E95F3EC03ECCD7 CRC64;
     MYCIEEKIEK ALGIKEASLV LKNCNIVNVF SSEIIRGDLA IDGDTIIGIG KYKGKTEIDL
     SNKYVAPGFI DSHVHIESSM VSPKEFARAV ISRGTTTIIV DPHEIANVCG MDGIKYMMEE
     TKNMPLDVFF MLSSCVPATS FETSGAVLKA EDLKELIDSD RVLGLGEMMN YPGVLSREEE
     VLNKLKLAGS YNKIVDGHAP SVRGNELNAY NLAGIKTDHE CSSIEEMNEK IRNGMYIAIR
     EGSAAKNLDI LIKGVNAKNE RRIMFCADDR HPDDILKSGH MDNCVRRAIY NGIENTAAIR
     MASINAAECY KLERVGAIAP SYKADLVVLE DLKDVKVNMV IKSGEVVFKD NKHLKDMGSK
     SDITKVSNTV NIKKVSEENL ELKLDTDVCS IISVALNSIS TKNVKRKVNL SNGIFKCELN
     YGINKVAVIE RHKKSGSIGI GLVENFGLKR GAIASTVAHD SHNIIVLGNN DEDMVKAVNE
     IERVGGGITI SLDGKIIETL ELEIAGLMSN KSMEFVAERV SKMINICHNT LGVNKDIQPF
     MTLAFLALPV IPEIRITDKG VFDVVNFKFL