ID   DPM3_PONAB              Reviewed;          92 AA.
AC   Q5R8B1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Dolichol-phosphate mannosyltransferase subunit 3;
DE   AltName: Full=Dolichol-phosphate mannose synthase subunit 3;
DE            Short=DPM synthase subunit 3;
DE   AltName: Full=Dolichyl-phosphate beta-D-mannosyltransferase subunit 3;
DE   AltName: Full=Mannose-P-dolichol synthase subunit 3;
DE            Short=MPD synthase subunit 3;
GN   Name=DPM3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stabilizer subunit of the dolichol-phosphate mannose (DPM)
CC       synthase complex; tethers catalytic subunit DPM1 to the endoplasmic
CC       reticulum. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBUNIT: Component of the dolichol-phosphate mannose (DPM) synthase
CC       complex composed of DPM1, DPM2 and DPM3; within the complex, associates
CC       with DPM1 via its C-terminal domain and with DPM2 via its N-terminal
CC       portion. This interaction stabilizes DPM1 protein.
CC       {ECO:0000250|UniProtKB:Q9P2X0}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DPM3 family. {ECO:0000305}.
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DR   EMBL; CR859842; CAH91999.1; -; mRNA.
DR   RefSeq; NP_001126160.1; NM_001132688.1.
DR   AlphaFoldDB; Q5R8B1; -.
DR   STRING; 9601.ENSPPYP00000000878; -.
DR   Ensembl; ENSPPYT00000000909; ENSPPYP00000000878; ENSPPYG00000000757.
DR   GeneID; 100173120; -.
DR   KEGG; pon:100173120; -.
DR   CTD; 54344; -.
DR   eggNOG; KOG4841; Eukaryota.
DR   GeneTree; ENSGT00390000008892; -.
DR   HOGENOM; CLU_150782_0_1_1; -.
DR   InParanoid; Q5R8B1; -.
DR   OrthoDB; 1612544at2759; -.
DR   TreeFam; TF300274; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0033185; C:dolichol-phosphate-mannose synthase complex; IEA:Ensembl.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:Ensembl.
DR   GO; GO:0019348; P:dolichol metabolic process; IEA:Ensembl.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR   InterPro; IPR013174; DPM3.
DR   PANTHER; PTHR16433; PTHR16433; 1.
DR   Pfam; PF08285; DPM3; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..92
FT                   /note="Dolichol-phosphate mannosyltransferase subunit 3"
FT                   /id="PRO_0000328451"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   92 AA;  10066 MW;  C3423F027ADB2377 CRC64;
     MTKLAQWLWG LAILGSTWAA LTTGALGLEL PLSCQEVLWP LPAYLLVSAG CYALGTVGYR
     VATFHDCEDA ARELQSQIQE ARADLARRGL RF