DPM3_SCHPO
ID DPM3_SCHPO Reviewed; 90 AA.
AC O94633;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Dolichol-phosphate mannosyltransferase subunit 3;
DE AltName: Full=DPM synthase complex subunit 3;
DE AltName: Full=Dolichol-phosphate mannose synthase subunit 3;
DE AltName: Full=Dolichyl-phosphate beta-D-mannosyltransferase subunit 3;
DE AltName: Full=Mannose-P-dolichol synthase subunit 3;
DE Short=MPD synthase subunit 3;
GN Name=dpm3; ORFNames=SPBC1677.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP CHARACTERIZATION.
RX PubMed=10835346; DOI=10.1093/emboj/19.11.2475;
RA Maeda Y., Tanaka S., Hino J., Kangawa K., Kinoshita T.;
RT "Human dolichol-phosphate-mannose synthase consists of three subunits,
RT DPM1, DPM2 and DPM3.";
RL EMBO J. 19:2475-2482(2000).
CC -!- FUNCTION: Stabilizer subunit of the dolichol-phosphate-mannose synthase
CC complex.
CC -!- SUBUNIT: Composed of three subunits; dpm1, dpm2 and dpm3.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DPM3 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB37621.1; -; Genomic_DNA.
DR PIR; T39515; T39515.
DR RefSeq; NP_596640.1; NM_001022562.2.
DR AlphaFoldDB; O94633; -.
DR SMR; O94633; -.
DR BioGRID; 276219; 3.
DR STRING; 4896.SPBC1677.02.1; -.
DR MaxQB; O94633; -.
DR PaxDb; O94633; -.
DR EnsemblFungi; SPBC1677.02.1; SPBC1677.02.1:pep; SPBC1677.02.
DR GeneID; 2539664; -.
DR KEGG; spo:SPBC1677.02; -.
DR PomBase; SPBC1677.02; dpm3.
DR VEuPathDB; FungiDB:SPBC1677.02; -.
DR eggNOG; KOG4841; Eukaryota.
DR HOGENOM; CLU_2442130_0_0_1; -.
DR InParanoid; O94633; -.
DR OMA; VATTHDK; -.
DR PhylomeDB; O94633; -.
DR Reactome; R-SPO-162699; Synthesis of dolichyl-phosphate mannose.
DR PRO; PR:O94633; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0033185; C:dolichol-phosphate-mannose synthase complex; ISO:PomBase.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; ISO:PomBase.
DR GO; GO:0006487; P:protein N-linked glycosylation; IC:PomBase.
DR GO; GO:0006493; P:protein O-linked glycosylation; IC:PomBase.
DR InterPro; IPR013174; DPM3.
DR PANTHER; PTHR16433; PTHR16433; 1.
DR Pfam; PF08285; DPM3; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..90
FT /note="Dolichol-phosphate mannosyltransferase subunit 3"
FT /id="PRO_0000195003"
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 90 AA; 10530 MW; 7DD0C4BF232F4510 CRC64;
MQRIHKVILY YVSLTILYRV TYLFDLEEPW STLRPYTPYL FILAFGSYLG ITLLYNVATT
NDKPEAYVDL VKDIKEAQDA LRSKGMTIED
