ID   DPO3A_CAUVC             Reviewed;        1143 AA.
AC   Q9A700;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA polymerase III subunit alpha;
DE            EC=2.7.7.7;
GN   Name=dnaE1; Synonyms=dnaE; OrderedLocusNames=CC_1926;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain
CC       is the DNA polymerase (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the PolIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE005673; AAK23901.1; -; Genomic_DNA.
DR   PIR; A87488; A87488.
DR   RefSeq; NP_420733.1; NC_002696.2.
DR   RefSeq; WP_010919792.1; NC_002696.2.
DR   AlphaFoldDB; Q9A700; -.
DR   SMR; Q9A700; -.
DR   STRING; 190650.CC_1926; -.
DR   EnsemblBacteria; AAK23901; AAK23901; CC_1926.
DR   KEGG; ccr:CC_1926; -.
DR   PATRIC; fig|190650.5.peg.1943; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_0_0_5; -.
DR   OMA; KQRFHLC; -.
DR   BioCyc; CAULO:CC1926-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0009432; P:SOS response; EXP:CollecTF.
DR   Gene3D; 1.10.10.1600; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA replication; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..1143
FT                   /note="DNA polymerase III subunit alpha"
FT                   /id="PRO_0000103316"
SQ   SEQUENCE   1143 AA;  125539 MW;  445F362DCC7DB92B CRC64;
     MSDAEGQGFV HLRVRSAYSL LEGAIKADQI GKLAAEAKMP AAGLADRANL FGALEYSSYA
     KDAGVQPIIG CAIPVVGIGG GPTERWARAP TLMLLAQNER GYLNLSELSS IAYLDSAELP
     EPVVPWAKVA EHSEGLILLS GGTDGPVDAL FAAGKTAEAS AALAEMHRVF GDRFYVELQR
     HGLPRQAAAE PGLVNWAYDH DVPLVATNDV YFAKPGFYDA HDALLCISDG AFVGQDERRR
     VTPEHWFKPA EEMRKLFADL PEACDNTLDI ARRCAFMVHK RDPILPSFPT GDGRNEAEEL
     EHQAREGLKM RLEGLTLSAP EEEYWKRLDF ELGIIKKMGF PGYFLIVSDF IKWGKAHGIP
     VGPGRGSGAG SLVAWVLTIT DLDPLRFGLL FERFLNPERV SMPDFDVDFC QERREEVISY
     VQEKYGRDRV AQIITFGSLQ ARAVLRDVGR VMQLPLGLVD RLCKMVPNNP AAPVTLAQAI
     DLEPRLKQAK KEDANVSACL DVALQLEGLF RNASTHAAGL VIGDRPLTQL TPLYKDPRSD
     LPATQFNMKW VESAGLVKFD FLGLKTLTVL DRAVKHLKKR GFEIDLGKLP FDDAKTYELL
     ASGQTVGVFQ LESQGMRDTL RKMRCGSIEE ITALISLYRP GPMDNIDTFV DCKFGRKPVD
     TLHPSLEAVL KETYGVIVYQ EQVMQIAQIL AGYSLGEADL LRRAMGKKKK EEMDLQKIRF
     VSGAKEKNVP EEQSGSIFEL VAKFAGYGFN KSHAAAYAFI SYQTAWLKAN TPVEFFAASM
     SLDLSNTDKL AVFHQDARRF GITVRAPDVN RSGADFEVEN GEVLYALGAI RNVGLEAMKH
     LVAVRAEGGP FRDVFDFVER IDPRQVNKRA IENLARAGAF DSIHKNRAQI VASADVLIAH
     AQSCHADRQG GQGGLFGSDP GAGRPRLSKT ENWNQVDLLD EELSAVGFYL TGHPLEDMVG
     MLRRRRTVML AEAMAQAEAG AEAFRMCGVV RRRQERASQS GEKFAFVSLS DPTGEYEVLY
     PPESLRKCRD VLEPGKAVAI KVRAKARDGE VRFFGDDAEP IEKAVENVVA GLRVHLSPSA
     AEIDALKRRL EPAQAQKGGE VTFVAAIGGG REIELRLPGR YTLDAALRGA LKTAPGVALL
     EDV