ID   DPO3A_CHLPN             Reviewed;        1240 AA.
AC   Q9Z7N8;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 133.
DE   RecName: Full=DNA polymerase III subunit alpha;
DE            EC=2.7.7.7;
GN   Name=dnaE; OrderedLocusNames=CPn_0666, CP_0081, CpB0692;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain
CC       is the DNA polymerase (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the PolIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE001363; AAD18805.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF37967.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA98873.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP98621.1; -; Genomic_DNA.
DR   PIR; B72050; B72050.
DR   PIR; G86573; G86573.
DR   RefSeq; NP_224862.1; NC_000922.1.
DR   RefSeq; WP_010883304.1; NZ_LN847257.1.
DR   AlphaFoldDB; Q9Z7N8; -.
DR   SMR; Q9Z7N8; -.
DR   STRING; 115711.CP_0081; -.
DR   EnsemblBacteria; AAD18805; AAD18805; CPn_0666.
DR   EnsemblBacteria; AAF37967; AAF37967; CP_0081.
DR   GeneID; 45050717; -.
DR   KEGG; cpa:CP_0081; -.
DR   KEGG; cpj:dnaE; -.
DR   KEGG; cpn:CPn_0666; -.
DR   KEGG; cpt:CpB0692; -.
DR   PATRIC; fig|115713.3.peg.736; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_0_0_0; -.
DR   OrthoDB; 561611at2; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.1600; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   InterPro; IPR010994; RuvA_2-like.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA replication; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..1240
FT                   /note="DNA polymerase III subunit alpha"
FT                   /id="PRO_0000103318"
SQ   SEQUENCE   1240 AA;  140076 MW;  7D6890EF002A88E4 CRC64;
     MTWIPLHCHS QYSVLDAMSS IKDFVAKGQE FGIPALALTD HGNLYGAVDF YKECTQKGIQ
     PIIGCECYIA PGSRFDKKKE KRSRAAHHLI LLCKNEQGYR NLCILTSLAF TEGFYYFPRI
     DKDLLRQYSE GLICLSGCLS SSVSDAALKS PEALLLELQW FQDLFKDDYF TEVQLHKMSE
     ESIAGFKEEW LKQEYYSLIE KQIKVNTAVL EASKRLGIPT VATNDIHYIN ANDWQAHEIL
     LNVQSGETVR IAKQNTHIPN PKRKVYRSRE YYFKSPAQMA ELFKDIPEVI SNTLEVAKRC
     DFTFDFSKKH YPIYVPESLK TLNSYTEEDR YQASAVFLKQ LAEEALPKKY SSEVLAHIAK
     KFPHRDPIDI VKERMDMEMA IIIPKGMCDY LLIVWDIIHW AKANGIPVGP GRGSGAGSVL
     LFLLGITEIE PIRFDLFFER FINPERLSYP DIDIDICMAG RERVINYAIE RHGKDNVAQI
     ITFGTMKAKM AVKDVGRTLD MALSKVNHIA KHIPDLNTTL SKALETDPDL HQLYINDAES
     AQVIDMALCL EGSIRNTGVH AAGVIICGDQ LTNHIPICIS KDSTMITTQY SMKPVESVGM
     LKVDLLGLKT LTSINIAMSA IEKKTGQSLA MATLPLDDAT TFSLLHQGKT MGIFQMESKG
     MQELAKNLRP DLFEEIIAMG ALYRPGPMDM IPSFINRKHG KEIIEYDHPL MESILKETYG
     IMVYQEQVMQ IAGALASYSL GEGDVLRRAM GKKDFQQMEQ EREKFCKRAC NNGIDPELAT
     VIFDKMEKFA AYGFNKSHAA AYGLITYTTA YLKANYPKEW LAALLTCDSD DIEKIGKLIR
     EAQSMGIPIL PPHINVSSNH FVATDEGIRF AMGAIKGIGR GLIESIVEER DHHGPYESIR
     DFIQRSDLKK VSKKSIESLI DAGCFDCFDS NRDLLLASVE PLYEAIAKDK KEAASGVMTF
     FTLGAMDRKN EVPICLPKDI PTRSKKELLK KEKELLGIYL TEHPMDTVRD HLSRLSVVLA
     GEFENLPHGS VVRTVFIIDK VTTKISSKAQ KKFAVLRVSD GIDSYELPIW PDMYEEQQEL
     LEEDRLIYAI LVLDKRSDSL RISCRWMKDL SIVNENIIYE CDQAFDRIKN QVQKMSFTMS
     TSGKETKAKG NKPNENGHTQ ALAPVTLSLD LNELRHSHLC ILKKIVQKHP GSRTLVLVFT
     QDNERVASMS PDDAYFVCED IEELRQELVT ADLPVRVITV