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DPO3A_RICBR
ID   DPO3A_RICBR             Reviewed;        1172 AA.
AC   Q1RKF9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA polymerase III subunit alpha;
DE            EC=2.7.7.7;
GN   Name=dnaE; OrderedLocusNames=RBE_0074;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RML369-C;
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae in
RT   gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain
CC       is the DNA polymerase (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the PolIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CP000087; ABE04155.1; -; Genomic_DNA.
DR   RefSeq; WP_011476770.1; NC_007940.1.
DR   AlphaFoldDB; Q1RKF9; -.
DR   SMR; Q1RKF9; -.
DR   STRING; 336407.RBE_0074; -.
DR   PRIDE; Q1RKF9; -.
DR   EnsemblBacteria; ABE04155; ABE04155; RBE_0074.
DR   KEGG; rbe:RBE_0074; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_0_0_5; -.
DR   OMA; NECRRMG; -.
DR   OrthoDB; 561611at2; -.
DR   Proteomes; UP000001951; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.1600; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA replication; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..1172
FT                   /note="DNA polymerase III subunit alpha"
FT                   /id="PRO_0000280955"
SQ   SEQUENCE   1172 AA;  131797 MW;  2A1B7972C2E6AE9B CRC64;
     MQTEFIHLRT QSSYSFLASA LTTEKIVELA SSYKMAAICL TDKENLFGSL EFALYAIKKG
     LQPIHGVILN IQYETGVFAE ILLIAKDETG YKNLLKLSSI TFTTNDRKIC NHITFEDLKE
     HQEGLITLCC YTEGVIGKCL LANKEEQAEM FARNLQEIFG DRFYFEIMRH DLPEEQLIED
     NYIKIASKLN IPLVATNKVL FSKKSMHDAH DVLLCISAGV TKEYPDRKTV SENCYFKSAK
     EMIELFADLP SAIENTVNLT QRCYFAAHTN PPMLPNFATK DISETDLIRK EAKDGLLARL
     DTKFKSEHIS IEHQESIKTE YFARLDYELN IICSMNFAGY FLIVSDFIKW SKKQGILVGP
     GRGSGAGSVV AWSLLITDLD PIKFGLLFER FLNPDRISMP DFDIDFCQER REEVINYVRS
     KYGNNRVGQI ITFGKMQAKA VIKDVARVLS LPYKFADYLT ELVPFSAINP VTLEQAIREV
     PELANAAKGN GLYNLEGELE LIKLVLDTSL ILEGLHRHSS THAAGIVIAG TDLVDIVPVY
     KDANSDMLVV GYSMKYCELA GLIKFDFLGL QTLTVITDCK KLLKEQNIEI DFNDMTFDDE
     KTYQMLCKGK GVGVFQFESV GMKDALRRLK PDSIHDLIAL GALYRPGPME NIPTYIACKH
     KLQQPDYLHE LLKPILEETY GVVIYQEQVQ RIAQVLAGYT LGAADLLRRA MGKKIKAEME
     QQEEIFVKGA IANNISEAQA KSIFATVAKF AGYGFNKAHA AAYGVISYQT AYLKANYPAE
     FVVACLNLEL NNHDKINLFL QEAKDNNIKI IAPNINISGG YFSVKSVIPR LDCGIHGDQL
     KDTAVKPQYD IDSSIIFALG AIKGVTPNFG KLVTDERNAR GAFKSIVDFI ERLPPKAINS
     KLLENLIKAG CFDELHDNRL QLFLSISKLL AYSVSYHEEQ ASNQFSLIKV SSLSKEILVS
     SDYADKNTLA FYEFEAMGLF ISNHPLTEYK EIFNRLNILS SADLHNNLPD GTNRVMIAGV
     IQKKDSRMSA RGRFVTLVLS DPENIFELSI FSEEVLKDYV HLLDVKSLVV VNCDIIKDEG
     GIKITAKSFS SIENATGNQQ FDLQLYPKND EELEQIITLL SARINNDEQS NTIATIYLSN
     KSVKNFVAKI TFPEKFFLKG QDFEILSIYQ NT
 
 
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