DPO3A_RICBR
ID DPO3A_RICBR Reviewed; 1172 AA.
AC Q1RKF9;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=DNA polymerase III subunit alpha;
DE EC=2.7.7.7;
GN Name=dnaE; OrderedLocusNames=RBE_0074;
OS Rickettsia bellii (strain RML369-C).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX NCBI_TaxID=336407;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RML369-C;
RX PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA Fournier P.-E., Claverie J.-M., Raoult D.;
RT "Genome sequence of Rickettsia bellii illuminates the role of amoebae in
RT gene exchanges between intracellular pathogens.";
RL PLoS Genet. 2:733-744(2006).
CC -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC responsible for most of the replicative synthesis in bacteria. This DNA
CC polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain
CC is the DNA polymerase (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC and theta chains) that associates with a tau subunit. This core
CC dimerizes to form the PolIII' complex. PolIII' associates with the
CC gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC and with the beta chain to form the complete DNA polymerase III complex
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE
CC subfamily. {ECO:0000305}.
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DR EMBL; CP000087; ABE04155.1; -; Genomic_DNA.
DR RefSeq; WP_011476770.1; NC_007940.1.
DR AlphaFoldDB; Q1RKF9; -.
DR SMR; Q1RKF9; -.
DR STRING; 336407.RBE_0074; -.
DR PRIDE; Q1RKF9; -.
DR EnsemblBacteria; ABE04155; ABE04155; RBE_0074.
DR KEGG; rbe:RBE_0074; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_0_0_5; -.
DR OMA; NECRRMG; -.
DR OrthoDB; 561611at2; -.
DR Proteomes; UP000001951; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.1600; -; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR004805; PolC_alpha.
DR PANTHER; PTHR32294; PTHR32294; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; SSF89550; 1.
DR TIGRFAMs; TIGR00594; polc; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA replication; DNA-directed DNA polymerase;
KW Nucleotidyltransferase; Transferase.
FT CHAIN 1..1172
FT /note="DNA polymerase III subunit alpha"
FT /id="PRO_0000280955"
SQ SEQUENCE 1172 AA; 131797 MW; 2A1B7972C2E6AE9B CRC64;
MQTEFIHLRT QSSYSFLASA LTTEKIVELA SSYKMAAICL TDKENLFGSL EFALYAIKKG
LQPIHGVILN IQYETGVFAE ILLIAKDETG YKNLLKLSSI TFTTNDRKIC NHITFEDLKE
HQEGLITLCC YTEGVIGKCL LANKEEQAEM FARNLQEIFG DRFYFEIMRH DLPEEQLIED
NYIKIASKLN IPLVATNKVL FSKKSMHDAH DVLLCISAGV TKEYPDRKTV SENCYFKSAK
EMIELFADLP SAIENTVNLT QRCYFAAHTN PPMLPNFATK DISETDLIRK EAKDGLLARL
DTKFKSEHIS IEHQESIKTE YFARLDYELN IICSMNFAGY FLIVSDFIKW SKKQGILVGP
GRGSGAGSVV AWSLLITDLD PIKFGLLFER FLNPDRISMP DFDIDFCQER REEVINYVRS
KYGNNRVGQI ITFGKMQAKA VIKDVARVLS LPYKFADYLT ELVPFSAINP VTLEQAIREV
PELANAAKGN GLYNLEGELE LIKLVLDTSL ILEGLHRHSS THAAGIVIAG TDLVDIVPVY
KDANSDMLVV GYSMKYCELA GLIKFDFLGL QTLTVITDCK KLLKEQNIEI DFNDMTFDDE
KTYQMLCKGK GVGVFQFESV GMKDALRRLK PDSIHDLIAL GALYRPGPME NIPTYIACKH
KLQQPDYLHE LLKPILEETY GVVIYQEQVQ RIAQVLAGYT LGAADLLRRA MGKKIKAEME
QQEEIFVKGA IANNISEAQA KSIFATVAKF AGYGFNKAHA AAYGVISYQT AYLKANYPAE
FVVACLNLEL NNHDKINLFL QEAKDNNIKI IAPNINISGG YFSVKSVIPR LDCGIHGDQL
KDTAVKPQYD IDSSIIFALG AIKGVTPNFG KLVTDERNAR GAFKSIVDFI ERLPPKAINS
KLLENLIKAG CFDELHDNRL QLFLSISKLL AYSVSYHEEQ ASNQFSLIKV SSLSKEILVS
SDYADKNTLA FYEFEAMGLF ISNHPLTEYK EIFNRLNILS SADLHNNLPD GTNRVMIAGV
IQKKDSRMSA RGRFVTLVLS DPENIFELSI FSEEVLKDYV HLLDVKSLVV VNCDIIKDEG
GIKITAKSFS SIENATGNQQ FDLQLYPKND EELEQIITLL SARINNDEQS NTIATIYLSN
KSVKNFVAKI TFPEKFFLKG QDFEILSIYQ NT