ID   DPO3A_UREPA             Reviewed;         969 AA.
AC   Q9PQ74;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=DNA polymerase III subunit alpha;
DE            EC=2.7.7.7;
GN   Name=dnaE; OrderedLocusNames=UU415;
OS   Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=273119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700970;
RX   PubMed=11048724; DOI=10.1038/35037619;
RA   Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA   Cassell G.H.;
RT   "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL   Nature 407:757-762(2000).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain
CC       is the DNA polymerase (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the PolIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF222894; AAF30826.1; -; Genomic_DNA.
DR   RefSeq; WP_006688481.1; NC_002162.1.
DR   AlphaFoldDB; Q9PQ74; -.
DR   SMR; Q9PQ74; -.
DR   STRING; 273119.UU415; -.
DR   EnsemblBacteria; AAF30826; AAF30826; UU415.
DR   GeneID; 29672555; -.
DR   KEGG; uur:UU415; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_0_1_14; -.
DR   OMA; MMREYIL; -.
DR   Proteomes; UP000000423; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.1600; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 2.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA replication; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..969
FT                   /note="DNA polymerase III subunit alpha"
FT                   /id="PRO_0000103357"
SQ   SEQUENCE   969 AA;  112344 MW;  0569486460E2960B CRC64;
     MFINLNVHSH YSLLNSTLSI DDLIKYALDN KQPYVCLTDL NNMYGCIEFY DKAKAHNLTP
     IIGLEFEYQN ATLVAYAKNY NGYLKLIKWS SWIMTSKEFE IQDDFDDLII VCKKGTIVFK
     SPNFYQTHDQ NAPNAIALQS VFYANKNDKI VFLAMLAIKN DLKLEDFKNC CDFDNNHFLN
     DNLAQSFFSP IALNNLNKVL NELKVQIHDL PINIPVYDKQ NSIISSEILK QLCISGLKKR
     LNANDGQVNK IYVQRLKYEL DVINEKQFDD YFLIVYDFIN FAKSNGIIVG PGRGSAAGSL
     VAYCLHITDI DPIKHNLIFE RFLNPTRKSM PDIDTDIMDE KRDLVIEYLF EKYGNDHVAY
     ILTFQRLKAK MAIRDVGRIL GIDLKVIDKI CKNIKPEYDE DLDLAIKKNT ILKEMYLLHK
     ELFEISKKLI NAPRQIGTHA AGIILSDSLI SNIIPIQLGI NDRPLSQYSM EYLERFGLIK
     MDLLGLKNLT IIDNVLKMIY ENQNKKIDLF NINYNDKFVF EDLAKARTNG IFQLESPGMK
     KVLLKVKPQN IEDISIVSAL FRPGPQQNIK TFVERRFKRE EFSYWNEATR KILEPTYGII
     VYQEQVIELV KTIANFDIAT SDNFRRAISK KDEKILIQLK DDFINGALNN NYKQPLVNQI
     FEYIFSFAHY GFNHSHSLAY SYISYWLAYL KHYYTLEFLS VLLSHTSASK DKLLSYLNEA
     KEFNISIKGP DIQYFSNDFV IDTQKQIIRF GFKTIKGFGD ELLKKIKSAL QKSTLSDYIS
     YIDALKKGNV SLKNIEILIR VGTFDSFGIN RLFLLNNLNE IFEKTGLNGH FFDLNLVGLD
     YAKDMSVNDR YLDDEIQYLG IDLNSLNYAN YKTEIDYNKL KYTIKDFYEI NTNYETNILA
     QVLNIKQSKT KNGNDIFYLE TLIDNKKQTL TIFQNSKYLI DEISIGGIYV FGVKLLNHFN
     FIVNIKQRI