ID   ADEC_DEIRA              Reviewed;         536 AA.
AC   Q9RYP0;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=DR_A0270;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE001825; AAF12490.1; -; Genomic_DNA.
DR   PIR; E75580; E75580.
DR   RefSeq; NP_285593.1; NC_001264.1.
DR   RefSeq; WP_010889529.1; NC_001264.1.
DR   AlphaFoldDB; Q9RYP0; -.
DR   SMR; Q9RYP0; -.
DR   STRING; 243230.DR_A0270; -.
DR   EnsemblBacteria; AAF12490; AAF12490; DR_A0270.
DR   KEGG; dra:DR_A0270; -.
DR   PATRIC; fig|243230.17.peg.3161; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_0; -.
DR   InParanoid; Q9RYP0; -.
DR   OMA; IEGHFPG; -.
DR   OrthoDB; 751534at2; -.
DR   Proteomes; UP000002524; Chromosome II.
DR   GO; GO:0000034; F:adenine deaminase activity; IBA:GO_Central.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..536
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000142416"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  55904 MW;  C4EA662B032EFA74 CRC64;
     MTPSPHDLLH CGMNSQDRDE TNGDRQRLVR VALGQEDGDL LVRGAQVVQP VTREVYAADV
     LVAGGRVAAV GPDLPARARR TVQARGAYLA PGFIDGHIHI ESSLLTPASF AAAVLPHGTT
     AVVAEPHEIV NVLGPAGLNW MLGAGRTSGL RVYASAPSCV PASEFEQGGA RVDAAQVAEM
     LARPGVLGLA EMMNYPGVLG GDAGVWDILN AGRRSGKRLD GHAAGLGGRE LLAYAAAGLH
     SDHEATTPEE ARERLRAGLW LMVREGSAAR NLAALLPVLR DLPRRALLVS DDVSVDELLE
     LGHLDRLLRT CVAGGLHPAD AVALVTSQPA EYWGLHDLGV IAPGYHADFV LLRDLQHFGV
     LETFVGGEEA RPGGETPPLP GGGVDLGPGW DGATFDPPAH WPTLQMFPDQ IVTGRAAPGS
     GDARLVVADR YGRGEWSSCW TLGSGLRGGT LGISILHDAH QVALLGGSDA DLRAAGRALE
     RLGGGIVLVV DGEVREQLPL PYAGLMTDHA PAEAAAALGR VTAAARLLGC MPAGRL