DPO3B_BUCAP
ID DPO3B_BUCAP Reviewed; 366 AA.
AC P29439;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Beta sliding clamp;
DE Short=Beta clamp;
DE Short=Sliding clamp;
DE AltName: Full=Beta-clamp processivity factor;
DE AltName: Full=DNA polymerase III beta sliding clamp subunit;
DE AltName: Full=DNA polymerase III subunit beta;
GN Name=dnaN; OrderedLocusNames=BUsg_011;
OS Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=198804;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1572539; DOI=10.1016/0378-1119(92)90393-4;
RA Lai C.-Y., Baumann P.;
RT "Genetic analysis of an aphid endosymbiont DNA fragment homologous to the
RT rnpA-rpmH-dnaA-dnaN-gyrB region of eubacteria.";
RL Gene 113:175-181(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9516544; DOI=10.1007/pl00006760;
RA Clark M.A., Baumann L., Baumann P.;
RT "Sequence analysis of a 34.7-kb DNA segment from the genome of Buchnera
RT aphidicola (endosymbiont of aphids) containing groEL, dnaA, the atp operon,
RT gidA, and rho.";
RL Curr. Microbiol. 36:158-163(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sg;
RX PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
CC -!- FUNCTION: Confers DNA tethering and processivity to DNA polymerases and
CC other proteins. Acts as a clamp, forming a ring around DNA (a reaction
CC catalyzed by the clamp-loading complex) which diffuses in an ATP-
CC independent manner freely and bidirectionally along dsDNA. Initially
CC characterized for its ability to contact the catalytic subunit of DNA
CC polymerase III (Pol III), a complex, multichain enzyme responsible for
CC most of the replicative synthesis in bacteria; Pol III exhibits 3'-5'
CC exonuclease proofreading activity. The beta chain is required for
CC initiation of replication as well as for processivity of DNA
CC replication. {ECO:0000250|UniProtKB:P0A988}.
CC -!- SUBUNIT: Forms a ring-shaped head-to-tail homodimer around DNA which
CC binds and tethers DNA polymerases and other proteins to the DNA. The
CC DNA replisome complex has a single clamp-loading complex (3 tau and 1
CC each of delta, delta', psi and chi subunits) which binds 3 Pol III
CC cores (1 core on the leading strand and 2 on the lagging strand) each
CC with a beta sliding clamp dimer. Additional proteins in the replisome
CC are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA
CC primase. {ECO:0000250|UniProtKB:P0A988}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0A988}.
CC -!- SIMILARITY: Belongs to the beta sliding clamp family. {ECO:0000305}.
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DR EMBL; M80817; AAA73150.1; -; Genomic_DNA.
DR EMBL; AF008210; AAC38107.1; -; Genomic_DNA.
DR EMBL; AE013218; AAM67583.1; -; Genomic_DNA.
DR PIR; JC1159; JC1159.
DR RefSeq; WP_011053549.1; NC_004061.1.
DR AlphaFoldDB; P29439; -.
DR SMR; P29439; -.
DR STRING; 198804.BUsg_011; -.
DR EnsemblBacteria; AAM67583; AAM67583; BUsg_011.
DR KEGG; bas:BUsg_011; -.
DR eggNOG; COG0592; Bacteria.
DR HOGENOM; CLU_038149_4_2_6; -.
DR OMA; KIACSLI; -.
DR OrthoDB; 1040142at2; -.
DR Proteomes; UP000000416; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00140; beta_clamp; 1.
DR InterPro; IPR001001; DNA_polIII_beta.
DR InterPro; IPR022635; DNA_polIII_beta_C.
DR InterPro; IPR022637; DNA_polIII_beta_cen.
DR InterPro; IPR022634; DNA_polIII_beta_N.
DR PANTHER; PTHR30478; PTHR30478; 1.
DR Pfam; PF00712; DNA_pol3_beta; 1.
DR Pfam; PF02767; DNA_pol3_beta_2; 1.
DR Pfam; PF02768; DNA_pol3_beta_3; 1.
DR PIRSF; PIRSF000804; DNA_pol_III_b; 1.
DR SMART; SM00480; POL3Bc; 1.
DR TIGRFAMs; TIGR00663; dnan; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW Nucleotidyltransferase; Transferase.
FT CHAIN 1..366
FT /note="Beta sliding clamp"
FT /id="PRO_0000105427"
SQ SEQUENCE 366 AA; 42180 MW; 9432FAB06CEFFDF1 CRC64;
MKFTIQNDIL TKNLKKITRV LVKNISFPIL ENILIQVEDG TLSLTTTNLE IELISKIEII
TKYIPGKTTI SGRKILNICR TLSEKSKIKM QLKNKKMYIS SENSNYILST LSADTFPNHQ
NFDYISKFDI SSNILKEMIE KTEFSMGKQD VRYYLNGMLL EKKDKFLRSV ATDGYRLAIS
YTQLKKDINF FSIIIPNKAV MELLKLLNTQ PQLLNILIGS NSIRIYTKNL IFTTQLIEGE
YPDYKSVLFK EKKNPIITNS ILLKKSLLRV AILAHEKFCG IEIKIENGKF KVLSDNQEEE
TAEDLFEIDY FGEKIEISIN VYYLLDVINN IKSENIALFL NKSKSSIQIE AENNSSNAYV
VMLLKR