ID   DPO3_LACPL              Reviewed;        1437 AA.
AC   Q88VK2; F9UQ02;
DT   03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=DNA polymerase III PolC-type {ECO:0000255|HAMAP-Rule:MF_00356};
DE            Short=PolIII {ECO:0000255|HAMAP-Rule:MF_00356};
DE            EC=2.7.7.7 {ECO:0000255|HAMAP-Rule:MF_00356};
GN   Name=polC {ECO:0000255|HAMAP-Rule:MF_00356}; OrderedLocusNames=lp_2045;
OS   Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS   (Lactobacillus plantarum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=220668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA   Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA   Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA   Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA   Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=22156394; DOI=10.1128/jb.06275-11;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   J. Bacteriol. 194:195-196(2012).
CC   -!- FUNCTION: Required for replicative DNA synthesis. This DNA polymerase
CC       also exhibits 3' to 5' exonuclease activity. {ECO:0000255|HAMAP-
CC       Rule:MF_00356}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00356};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00356}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. PolC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00356}.
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DR   EMBL; AL935263; CCC79291.1; -; Genomic_DNA.
DR   RefSeq; WP_003640729.1; NC_004567.2.
DR   RefSeq; YP_004889805.1; NC_004567.2.
DR   AlphaFoldDB; Q88VK2; -.
DR   SMR; Q88VK2; -.
DR   STRING; 220668.lp_2045; -.
DR   PRIDE; Q88VK2; -.
DR   EnsemblBacteria; CCC79291; CCC79291; lp_2045.
DR   GeneID; 57025597; -.
DR   KEGG; lpl:lp_2045; -.
DR   PATRIC; fig|220668.9.peg.1730; -.
DR   eggNOG; COG2176; Bacteria.
DR   HOGENOM; CLU_003297_0_0_9; -.
DR   OMA; YYAAYFT; -.
DR   PhylomeDB; Q88VK2; -.
DR   BioCyc; LPLA220668:G1GW0-1752-MON; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.700; -; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   HAMAP; MF_00356; DNApol_PolC; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR024754; DNA_PolC-like_N_II.
DR   InterPro; IPR028112; DNA_PolC-type_N_I.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR006054; DnaQ.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR006308; PolC_gram_pos.
DR   InterPro; IPR044923; PolC_middle_finger_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF14480; DNA_pol3_a_NI; 1.
DR   Pfam; PF11490; DNA_pol3_a_NII; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 2.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   TIGRFAMs; TIGR00573; dnaq; 1.
DR   TIGRFAMs; TIGR01405; polC_Gram_pos; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA replication; DNA-directed DNA polymerase; Exonuclease;
KW   Hydrolase; Nuclease; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..1437
FT                   /note="DNA polymerase III PolC-type"
FT                   /id="PRO_0000204578"
FT   DOMAIN          422..578
FT                   /note="Exonuclease"
FT   REGION          196..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1437 AA;  162045 MW;  EA6A81D70788D952 CRC64;
     MSLNQQEMFE KLLEQIEMPT GPEFTEAAID KLTVHQASKV WEFHLHFQHV LPYTQFMTFQ
     NKLQIAFKEI ARVTFTIVTD DTEVNGRELA EYWEWIVQHS GIKSPLVQSL CNSNVPTYED
     GRVILLAENE VIQNFLTNQA LGPIESTYHR LGFPKFSVHT MIDESASQAK IKEFHEQKAK
     SDQALAQKAE AAIKKANEKR QKQADAPAPI DGPVQLGKQI NPQEPAKQMV QITEEERSVV
     VEGYVFDMEV RTLRSQRQLL ILKVTDYSSS MVVKKFSRNA DDEAQFAALK PGMWVRVRGS
     VQEDSFMRDL TINAYDINET SHASRQDTAP ADEKRVELHL HSNMSQMDAT NSVSDYVKQA
     AKWGHPAIAI TDHSGAQAFP EAFAAGEKNN IKILYGVEAN MVDDGVPIAY NDAHVDLKES
     TYVIFDTETT GLSAIYDRVI ELSAVKMVKG NVVDQFEEFI DPGFHLSETT TNLTSITDDM
     VRGSKSEEEV FKLFREFYGD AIVVGHNVTF DIGFMNTGYA RHHMGPITNP IIDTLTLARW
     LYPNLRGYRL NTLAKKFNVN LEHHHRAIYD AETTGHLNHL FLKDAEDRYQ VQFHDQLNDH
     MNENAAYRHA RPFHATLYAQ TQAGLKNLFR IISLSNVEYY YRVPRVPRSV LNKYRDGILV
     GSACSSGEVF TAMMQKGKEE ARQKAGYYDF LEVQPKPAYS ALIESGLIAD TDHLEEIISN
     MVELGHEMNI PVAATGDVHY LNPEDKIYRK ILIHSQPGNP LNRTERPDVH FRSTDEMLKD
     FDFLGTETAH EVVVDTPRAL ADQFEIVRPV KDKLYTPRMK GAEAEIEKLT MDRAHAWYGN
     PLPEIVQKRV DKELKSIIGN GFSVIYLIAQ RLVFKSNKDG YLVGSRGSVG SSIVATLSGI
     TEVNPMPPHY RCPNCQYSHF YTNNEYGSGY DLPPKDCPEC GTDMVRDGQN IPFETFLGFY
     GNKVPDIDLN FSGDYQPIAH NYTKVLFGEK NVYRAGTIGT VADKTGYGYV KAYERDTNQT
     LRSAEVDRLA KGTTGVKRTT GQHPAGIIVV PDYMDIYDFT PVQYPADDQS AAWQTTHFDF
     HSIHDNILKI DILGHDDPTM IRMLQDLSGV QPESIPPVDP HVMKIFSSPE VLGVTEDQIF
     SKTGTLGIPE FGTRFVRGML EETHPSTFNE LLQISGLSHG TDVWLGNAEE LIKDGTVTLA
     EVIGCRDNIM TDLIHYGMES DMSFQIMEHV RKGRGIPDEW QQAMKDANVP DWYIESCLKI
     KYMFPRAHAA AYILMALRVA YFKVYFPLIY YTAYFSVRAD DFDLVAMAHG KDAVKASMKA
     ITDKGMDASA KEKNLLTVLE LANEMLERGF KFSMVDLDKS DASDWLIDGD TLIAPFRAVP
     GLGLNVAKQI VAARADKPFL SKEDLSKRGK VSKSLIDFMT ENGVLSDLPD ENQLSLF