ID   ADEC_FLAPJ              Reviewed;         540 AA.
AC   A6GYI0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=FP1059;
OS   Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 /
OS   JIP02/86).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=402612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86;
RX   PubMed=17592475; DOI=10.1038/nbt1313;
RA   Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B.,
RA   Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F.,
RA   Claverol S., Dumetz F., Le Henaff M., Benmansour A.;
RT   "Complete genome sequence of the fish pathogen Flavobacterium
RT   psychrophilum.";
RL   Nat. Biotechnol. 25:763-769(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM398681; CAL43153.1; -; Genomic_DNA.
DR   RefSeq; WP_011963204.1; NC_009613.3.
DR   RefSeq; YP_001295964.1; NC_009613.3.
DR   AlphaFoldDB; A6GYI0; -.
DR   SMR; A6GYI0; -.
DR   STRING; 402612.FP1059; -.
DR   EnsemblBacteria; CAL43153; CAL43153; FP1059.
DR   GeneID; 66552457; -.
DR   KEGG; fps:FP1059; -.
DR   PATRIC; fig|402612.5.peg.1073; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_10; -.
DR   OMA; TDHECFT; -.
DR   Proteomes; UP000006394; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..540
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000300158"
SQ   SEQUENCE   540 AA;  59529 MW;  768C691DA098CF86 CRC64;
     MQIQGQIVDI ENKRIYSGEI TIQNGKIISI IEKNHEVKNY ILPGFIDAHI HIESSMLVPS
     EFAKIAVLHG TVATISDPHE IANVLGKKGV YYMIENGKQV PLKFHFGAPS CVPATAFETA
     GAIIDSEEIK ELMASPDIYY LSEMMNYPGV LFDDDEVLKK IAWAKHFNKP IDGHAPGLRG
     EPIKKYISAG ITTDHECFTY SEAQEKLSLG MKVIIREGSA AKNFEALIDL LPANYENMMF
     CSDDKHPDDL ILGHINLLCA RAVAKGIDVF KILQVACVNP VHHYKMKVGL LKKNDAADFI
     VVEDLVNFKV NKTYINGELV AENGQSFVEN INFETPNNFN ITKKKISDFE IPSLAEKIRV
     IEALEGQLIT NEIHHNSFIK NGKLVSDIEN DILKMAVVNR YQNTTPAIAF IKNFGLKKGA
     IASSVAHDCH NIVVVGTSDE EICNAVNLII KNTGGICAVN GTQNKSLALP VAGIMSDKDA
     WETGKLYQEI DAMAKDLGST LKAPFMTLSF MALLVIPDLK LSDKGLFSGN TFSFVDLNVE