ID   ADEC_LACPL              Reviewed;         563 AA.
AC   Q88SR1; F9UTK9;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC;
GN   OrderedLocusNames=lp_3334;
OS   Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS   (Lactobacillus plantarum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=220668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA   Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA   Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA   Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA   Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=22156394; DOI=10.1128/jb.06275-11;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   J. Bacteriol. 194:195-196(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; AL935263; CCC80327.1; -; Genomic_DNA.
DR   RefSeq; WP_011102113.1; NC_004567.2.
DR   RefSeq; YP_004890841.1; NC_004567.2.
DR   AlphaFoldDB; Q88SR1; -.
DR   SMR; Q88SR1; -.
DR   STRING; 220668.lp_3334; -.
DR   DNASU; 1063932; -.
DR   EnsemblBacteria; CCC80327; CCC80327; lp_3334.
DR   KEGG; lpl:lp_3334; -.
DR   PATRIC; fig|220668.9.peg.2779; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; TDHECFT; -.
DR   PhylomeDB; Q88SR1; -.
DR   BioCyc; LPLA220668:G1GW0-2817-MON; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..563
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000142426"
SQ   SEQUENCE   563 AA;  60927 MW;  A4B5159C11718FA7 CRC64;
     MTKTVEMVIT GAQVLNVYTR EFEATSLWID HGRIISNLRD EPYIAAQHVD ATGQWIVPGM
     IDAHVHMESS MVAPSELGKV LLQHGVTTIA TDPHELANVA GIAGIQYLID DARQTPLDVC
     FMLPSSVPCV PFDDNGATLH AADLRPLYQQ SEVRGLAEVM DYGAVARGDT DTLAKISDAY
     AYGYHADGHA AGLNAHQLNV MRNAGLDTDH ECMTVAEAQD RVRAGMAVFL REGTVERDVL
     PTIGAVTEAN ASRFAFCTDD KMISDLLTEG SIDYNVRLAM QSGMRPELAY TLASLNGAMA
     HRLSDRGSLS AGQLADLVVL DDLEHVRIAR TMKRGQWILP STTKPLPFTA TRVQHHAQLA
     DFQLPLATGL ANVIGVQPNH IETDHLTLPI DATQNFEADC QRDILKMVVI ERHHNTGKVG
     VGLVHGFALK QGAIAGTVAH DAHNIVAVGT SDAAILRAVA QITQDNGGIA VVDNEQVLAT
     MPLAIGGLLS AASYQKVAEQ LAELKRAYEV ISERPLSFDP FITLSFLTLP VIPTLKLTAR
     GLFDYATFDF IPVAIQDNQR QTV