ID   DPOD2_CAEEL             Reviewed;         451 AA.
AC   Q19366;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Probable DNA polymerase delta small subunit;
DE            EC=2.7.7.7;
GN   ORFNames=F12F6.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: The function of the small subunit is not yet clear.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: Heterodimer with subunits of 125 kDa and 50 kDa.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase delta/II small subunit
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z73425; CAA97785.1; -; Genomic_DNA.
DR   PIR; T20798; T20798.
DR   RefSeq; NP_502177.1; NM_069776.4.
DR   AlphaFoldDB; Q19366; -.
DR   SMR; Q19366; -.
DR   BioGRID; 43174; 12.
DR   IntAct; Q19366; 1.
DR   STRING; 6239.F12F6.7.1; -.
DR   EPD; Q19366; -.
DR   PaxDb; Q19366; -.
DR   PeptideAtlas; Q19366; -.
DR   PRIDE; Q19366; -.
DR   EnsemblMetazoa; F12F6.7.1; F12F6.7.1; WBGene00008722.
DR   GeneID; 178077; -.
DR   KEGG; cel:CELE_F12F6.7; -.
DR   UCSC; F12F6.7.1; c. elegans.
DR   CTD; 178077; -.
DR   WormBase; F12F6.7; CE05595; WBGene00008722; -.
DR   eggNOG; KOG2732; Eukaryota.
DR   GeneTree; ENSGT00390000006780; -.
DR   HOGENOM; CLU_021763_0_0_1; -.
DR   InParanoid; Q19366; -.
DR   OMA; DPANFML; -.
DR   OrthoDB; 736068at2759; -.
DR   PhylomeDB; Q19366; -.
DR   Reactome; R-CEL-110314; Recognition of DNA damage by PCNA-containing replication complex.
DR   Reactome; R-CEL-5651801; PCNA-Dependent Long Patch Base Excision Repair.
DR   Reactome; R-CEL-5656169; Termination of translesion DNA synthesis.
DR   Reactome; R-CEL-5696397; Gap-filling DNA repair synthesis and ligation in GG-NER.
DR   Reactome; R-CEL-5696400; Dual Incision in GG-NER.
DR   Reactome; R-CEL-6782135; Dual incision in TC-NER.
DR   Reactome; R-CEL-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-CEL-69091; Polymerase switching.
DR   Reactome; R-CEL-69166; Removal of the Flap Intermediate.
DR   Reactome; R-CEL-69183; Processive synthesis on the lagging strand.
DR   PRO; PR:Q19366; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00008722; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0043625; C:delta DNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0042575; C:DNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006271; P:DNA strand elongation involved in DNA replication; IBA:GO_Central.
DR   CDD; cd07387; MPP_PolD2_C; 1.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR040663; DNA_pol_D_N.
DR   InterPro; IPR024826; DNA_pol_delta/II_ssu.
DR   InterPro; IPR041863; PolD2_C.
DR   PANTHER; PTHR10416; PTHR10416; 1.
DR   Pfam; PF18018; DNA_pol_D_N; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Nucleus; Reference proteome; Transferase.
FT   CHAIN           1..451
FT                   /note="Probable DNA polymerase delta small subunit"
FT                   /id="PRO_0000096169"
SQ   SEQUENCE   451 AA;  50404 MW;  6DCC014A809942C6 CRC64;
     METAWSNILN YKNVSDRYIL TEKDKKGAFT RQYFEVYEAR LKELKPRILE NAEREIGKGK
     FTHSQLSDAK QDEEIFVVGV IVKRIAARPS ILKSLLNEDK VAYDDYEEDA EEDEVKRYAG
     SIEDRIELES DKQTVRLEGN ISMDECATGC CVGVLGKLGK EGVFHVNRLV WPSVKVPKKV
     AVDGTIAFVS GLDLTGDLED DRLTISGLEF MADWMNVQVG NENQCPPIDR LVVIGPLVET
     KSNGCDVQSV VRTLTLSRAE KHSSTASLIT VDKIINSIAE KPLVNTVDVT PGVGDPCSSM
     WPLPPIHRVC LPRCGMSDKK VNLVTNPYEF EVNGLRVMTM SGENVSELLR TSLKWTGADA
     IENIIKWQHV APNCPDTLDA FPVAERDPLI MDITPHVIIC GNQPHAEFRH IPIDGSNCLV
     VCLPKFSKTR VACFLNLSDL SLKWQNFDHQ F