ID   ADEC_LISMF              Reviewed;         579 AA.
AC   Q71YS6;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518};
GN   OrderedLocusNames=LMOf2365_1767;
OS   Listeria monocytogenes serotype 4b (strain F2365).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=265669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F2365;
RX   PubMed=15115801; DOI=10.1093/nar/gkh562;
RA   Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F.,
RA   Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D.,
RA   White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M.,
RA   Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Haft D.H.,
RA   Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A.,
RA   Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O.,
RA   Luchansky J.B., Fraser C.M.;
RT   "Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne
RT   pathogen Listeria monocytogenes reveal new insights into the core genome
RT   components of this species.";
RL   Nucleic Acids Res. 32:2386-2395(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; AE017262; AAT04538.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q71YS6; -.
DR   SMR; Q71YS6; -.
DR   KEGG; lmf:LMOf2365_1767; -.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; TDHECFT; -.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese.
FT   CHAIN           1..579
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000142428"
SQ   SEQUENCE   579 AA;  62057 MW;  0A37715F6BE00005 CRC64;
     MENLEQLQER VAVSDGRAKA DLVIKNGRII NVFSGEIMDG DIAIKNGYIA GIGNFPDAEK
     IIDAAGAFIA PGFIDAHVHV ESAMVTPAEF ARVLLPNGVT TIVTDPHEIA NVAGEKGIEF
     MLEDAKGVPI DMFVMLPSSV PATEGEHNGE TLHAEKLHPL YRHEKVIGLA EVMDFPSVAK
     GSSDILTKII DAKKEGGRID GHGAGLTSAD LNNYLAVGIR TDHESTTAKE ATDRLRAGMF
     VMLREGTVGR DLLQTIPAVS EKNSHRFCFC TDDKLINDLI TEGSINYNIR LAIKNGIDPI
     TAIQMATINA ANCHNLPYLG AVAAGYQADI VFLTDIETVE ISKVLKNGEV VVDNGVRHEA
     AFKQQAAVPF VSPPINHHVS LQDLALPLTK ETCYVIGMQP NSLFTEKRIE QVAIQDGKFV
     PTVENDLLKM AVVERHHDTG CVGLGIVKGF GLTEGAIATT VAHDSHNIVA VGISDEAMKA
     AIDHITQTGG GIAVVNGAGQ VLHDLALPIA GLLSDKSYEE VENDLAGLLN AFKQISTADG
     FDPFLTLSFL TLPVIPELKL TDQGLFDFAT FQIISNEVN