DPOD4_SCHPO
ID DPOD4_SCHPO Reviewed; 160 AA.
AC O59835;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=DNA polymerase delta subunit 4;
GN Name=cdm1; ORFNames=SPBC12D12.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9799358; DOI=10.1007/s002940050394;
RA Reynolds N., Watt A., Fantes P.A., MacNeill S.A.;
RT "Cdm1, the smallest subunit of DNA polymerase d in the fission yeast
RT Schizosaccharomyces pombe, is non-essential for growth and division.";
RL Curr. Genet. 34:250-258(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Appears to have a role in the stabilization of the DNA
CC polymerase delta complex.
CC -!- SUBUNIT: Heterotetramer that consist of the pol3, cdc1, cdc27 and cdm1
CC subunits. Interacts with cdc1 and pol3.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA polymerase delta subunit 4 family.
CC {ECO:0000305}.
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DR EMBL; AJ006032; CAA06824.1; -; mRNA.
DR EMBL; CU329671; CAA22676.1; -; Genomic_DNA.
DR PIR; T39382; T39382.
DR RefSeq; NP_595948.1; NM_001021857.2.
DR AlphaFoldDB; O59835; -.
DR SMR; O59835; -.
DR BioGRID; 276552; 28.
DR ComplexPortal; CPX-2100; DNA polymerase delta complex.
DR STRING; 4896.SPBC12D12.02c.1; -.
DR PaxDb; O59835; -.
DR EnsemblFungi; SPBC12D12.02c.1; SPBC12D12.02c.1:pep; SPBC12D12.02c.
DR GeneID; 2540008; -.
DR KEGG; spo:SPBC12D12.02c; -.
DR PomBase; SPBC12D12.02c; cdm1.
DR VEuPathDB; FungiDB:SPBC12D12.02c; -.
DR eggNOG; ENOG502SC9I; Eukaryota.
DR HOGENOM; CLU_1628037_0_0_1; -.
DR InParanoid; O59835; -.
DR OMA; GPYLGMT; -.
DR PhylomeDB; O59835; -.
DR Reactome; R-SPO-110314; Recognition of DNA damage by PCNA-containing replication complex.
DR Reactome; R-SPO-174437; Removal of the Flap Intermediate from the C-strand.
DR Reactome; R-SPO-5358565; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
DR Reactome; R-SPO-5358606; Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).
DR Reactome; R-SPO-5651801; PCNA-Dependent Long Patch Base Excision Repair.
DR Reactome; R-SPO-5656169; Termination of translesion DNA synthesis.
DR Reactome; R-SPO-5696397; Gap-filling DNA repair synthesis and ligation in GG-NER.
DR Reactome; R-SPO-5696400; Dual Incision in GG-NER.
DR Reactome; R-SPO-6782135; Dual incision in TC-NER.
DR Reactome; R-SPO-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR Reactome; R-SPO-69091; Polymerase switching.
DR Reactome; R-SPO-69166; Removal of the Flap Intermediate.
DR Reactome; R-SPO-69183; Processive synthesis on the lagging strand.
DR PRO; PR:O59835; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0043625; C:delta DNA polymerase complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006271; P:DNA strand elongation involved in DNA replication; IDA:PomBase.
DR GO; GO:0000731; P:DNA synthesis involved in DNA repair; IBA:GO_Central.
DR GO; GO:1904161; P:DNA synthesis involved in UV-damage excision repair; IDA:PomBase.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR GO; GO:1903459; P:mitotic DNA replication lagging strand elongation; IC:PomBase.
DR GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
DR InterPro; IPR007218; DNA_pol_delta_4.
DR PANTHER; PTHR14303; PTHR14303; 1.
DR Pfam; PF04081; DNA_pol_delta_4; 1.
PE 2: Evidence at transcript level;
KW DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW Nucleus; Reference proteome; Transferase.
FT CHAIN 1..160
FT /note="DNA polymerase delta subunit 4"
FT /id="PRO_0000186053"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 160 AA; 18588 MW; 5681068D03BEAFBF CRC64;
MKKRTTQAKK SGQNTNIRDV FPHVVRSNSS QSHIGKKVSS EQSPTPDVTI TTKTLDERIK
EDDELSKEVE EAWNQIMAER ISEPIHCENI TKVEFILHHF DTTARYGPYL GMTRMQRWKR
AKNFNLNPPE TVGKILMLEE ADEENRKRES LFYDLQTIPG
