ID   ADEC_LISMO              Reviewed;         580 AA.
AC   Q8Y6E5;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC;
GN   OrderedLocusNames=lmo1742;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL591981; CAC99820.1; -; Genomic_DNA.
DR   PIR; AF1292; AF1292.
DR   RefSeq; NP_465267.1; NC_003210.1.
DR   RefSeq; WP_010989802.1; NC_003210.1.
DR   AlphaFoldDB; Q8Y6E5; -.
DR   SMR; Q8Y6E5; -.
DR   STRING; 169963.lmo1742; -.
DR   PaxDb; Q8Y6E5; -.
DR   PRIDE; Q8Y6E5; -.
DR   EnsemblBacteria; CAC99820; CAC99820; CAC99820.
DR   GeneID; 985560; -.
DR   KEGG; lmo:lmo1742; -.
DR   PATRIC; fig|169963.11.peg.1785; -.
DR   eggNOG; COG1001; Bacteria.
DR   HOGENOM; CLU_027935_0_0_9; -.
DR   OMA; TDHECFT; -.
DR   PhylomeDB; Q8Y6E5; -.
DR   BioCyc; LMON169963:LMO1742-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IBA:GO_Central.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..580
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000142429"
SQ   SEQUENCE   580 AA;  62125 MW;  C88B2DF4FA21EACB CRC64;
     MVENLKQLQE RVAVSDGRAK ADLVIKNGRI INVFSGEIMD GDIAIKNGYI AGIGSFPDAE
     KIIDAAGAFI APGFIDAHVH VESAMVTPAE FARVLLPNGV TTIVTDPHEI ANVAGEKGIE
     FMLEDAKGAP LDMFVMLPSS VPATEGEHNG ETLHAEKLHP LYRHEKVIGL AEVMDFPSVA
     KGSDDILRKI IDAKKEGGRI DGHGAGLTSA DLNNYLAVGI RTDHESTTAK EATDRLRAGM
     FVMLREGTVG RDLLQTIPAV SEKNSHRFCF CTDDKLINDL ITEGSINYNI KLAIKNGIDP
     ITAIQMATIN AANCHNLPYL GAVAAGYQAD IVFLTDIETV EISKVLKNGE VVVDNGVRNE
     AAFKQQAAVP FVSPPINHHV HLQDLALPLT KETCYVIGMQ PNSLFTEKRI EQVTIQGGKF
     VPTVENDLLK MAVVERHHDT GCVGVGIVKG FGLTEGAIAT TVAHDSHNIV AVGVSDEAMK
     AAIDHITQTG GGIAVVNGAG QVLHDLALPI AGLLSDKSYE EVENDLAGLL NAFKQISTAN
     GFDPFLTLSF LTLPVIPELK LTDQGLFDFA TFQIISNEVN