ID   DPOE2_BOVIN             Reviewed;         527 AA.
AC   A7YWS7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=DNA polymerase epsilon subunit 2;
DE   AltName: Full=DNA polymerase II subunit 2;
DE   AltName: Full=DNA polymerase epsilon subunit B;
GN   Name=POLE2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory component of the DNA polymerase epsilon complex (By
CC       similarity). Participates in DNA repair and in chromosomal DNA
CC       replication (By similarity). {ECO:0000250|UniProtKB:P24482,
CC       ECO:0000250|UniProtKB:P56282}.
CC   -!- SUBUNIT: Component of the DNA polymerase epsilon complex consisting of
CC       four subunits: the catalytic subunit POLE and the accessory subunits
CC       POLE2, POLE3 and POLE4. {ECO:0000250|UniProtKB:P56282}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC       beta, gamma, delta, and epsilon which are responsible for different
CC       reactions of DNA synthesis.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; BC134762; AAI34763.1; -; mRNA.
DR   RefSeq; NP_001098853.1; NM_001105383.2.
DR   AlphaFoldDB; A7YWS7; -.
DR   SMR; A7YWS7; -.
DR   STRING; 9913.ENSBTAP00000006488; -.
DR   PaxDb; A7YWS7; -.
DR   PRIDE; A7YWS7; -.
DR   GeneID; 518653; -.
DR   KEGG; bta:518653; -.
DR   CTD; 5427; -.
DR   eggNOG; KOG3818; Eukaryota.
DR   InParanoid; A7YWS7; -.
DR   OrthoDB; 375960at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR024639; DNA_pol_e_bsu_N.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708; PTHR12708; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
DR   Pfam; PF12213; Dpoe2NT; 1.
DR   PIRSF; PIRSF000799; DNA_pol_eps_2; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..527
FT                   /note="DNA polymerase epsilon subunit 2"
FT                   /id="PRO_0000328401"
SQ   SEQUENCE   527 AA;  59496 MW;  E261937D06F5D94E CRC64;
     MAPERLRSRA LSAFKLRGLM LRGEAVKYLT EALQSINEIE LEDALEKIID AVEKQPLSSN
     MIERSVVEAA VQECSQSVDE TIDHIFNIIG AFDIPRFVYN SERKKFLPLL MTNHPAPNLF
     GTARDKAELF RERYTILHQR THRHELFTPP VIGSHPDESG SKFQLKTIET LLGSTSKIGD
     VIVLGMITQL KEGKFFLEDP TGTIQLDLSK AQFHSGLYTE SCFVLAEGWF EDQVFHVNAF
     GFPPTEPSST TRAYYGNTNF FGGPSNTSVK TSAKLKQLED ENKDAMFVFI SDVWLDQVEV
     LEKLHIMFSG YSPAPPTCFI LCGNFSSAPY GKNQVQALKD SLKTLADIIC GYPNIHQSSR
     FVFVPGPEDP GFGSILPRPP FAESITNEFR QRVPFSVFTT NPCRIQYCTQ EIIVFREDLV
     NKMCRNCVRF PSSNLDIPNH FVKTVLSQGH LTPLPLYVCP VYWAYDYALR VYPVPDLLVI
     ADKYDPFTLT NTECLCINPG SFPRSGFSFK VFYPSNKVVE DSKLQGF