ID   DPOE2_CAEEL             Reviewed;         534 AA.
AC   Q19196;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Probable DNA polymerase epsilon subunit 2;
DE   AltName: Full=DNA polymerase II subunit 2;
DE   AltName: Full=DNA polymerase epsilon subunit B;
GN   Name=pole-2; ORFNames=F08B4.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Accessory component of the DNA polymerase epsilon complex (By
CC       similarity). Participates in DNA repair and in chromosomal DNA
CC       replication (By similarity). {ECO:0000250|UniProtKB:P24482,
CC       ECO:0000250|UniProtKB:P56282}.
CC   -!- SUBUNIT: Consists of four subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC       beta, gamma, delta, and epsilon which are responsible for different
CC       reactions of DNA synthesis.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; FO080903; CCD67651.1; -; Genomic_DNA.
DR   PIR; T29484; T29484.
DR   RefSeq; NP_501489.3; NM_069088.5.
DR   AlphaFoldDB; Q19196; -.
DR   SMR; Q19196; -.
DR   BioGRID; 42783; 3.
DR   STRING; 6239.F08B4.5; -.
DR   EPD; Q19196; -.
DR   PaxDb; Q19196; -.
DR   PeptideAtlas; Q19196; -.
DR   EnsemblMetazoa; F08B4.5.1; F08B4.5.1; WBGene00017237.
DR   GeneID; 177673; -.
DR   KEGG; cel:CELE_F08B4.5; -.
DR   UCSC; F08B4.5; c. elegans.
DR   CTD; 177673; -.
DR   WormBase; F08B4.5; CE49630; WBGene00017237; pole-2.
DR   eggNOG; KOG3818; Eukaryota.
DR   GeneTree; ENSGT00390000012435; -.
DR   HOGENOM; CLU_010628_2_1_1; -.
DR   InParanoid; Q19196; -.
DR   OrthoDB; 375960at2759; -.
DR   PhylomeDB; Q19196; -.
DR   Reactome; R-CEL-110314; Recognition of DNA damage by PCNA-containing replication complex.
DR   Reactome; R-CEL-5651801; PCNA-Dependent Long Patch Base Excision Repair.
DR   Reactome; R-CEL-5656169; Termination of translesion DNA synthesis.
DR   Reactome; R-CEL-5696397; Gap-filling DNA repair synthesis and ligation in GG-NER.
DR   Reactome; R-CEL-5696400; Dual Incision in GG-NER.
DR   Reactome; R-CEL-6782135; Dual incision in TC-NER.
DR   Reactome; R-CEL-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-CEL-68952; DNA replication initiation.
DR   Reactome; R-CEL-68962; Activation of the pre-replicative complex.
DR   PRO; PR:Q19196; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00017237; Expressed in embryo and 4 other tissues.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR024639; DNA_pol_e_bsu_N.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708; PTHR12708; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
DR   Pfam; PF12213; Dpoe2NT; 1.
DR   PIRSF; PIRSF000799; DNA_pol_eps_2; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..534
FT                   /note="Probable DNA polymerase epsilon subunit 2"
FT                   /id="PRO_0000071565"
SQ   SEQUENCE   534 AA;  60997 MW;  DC7E759CDE9CBE9A CRC64;
     MDTTAEENAL RREIVKTFQI HAFELKKEAV KLCVKLFLDH DKETRKKWTN KMIELLKKQT
     LQSSLISEEL IRDTFRQCKS KGTQDAGKLL NVFDAFSLQP YDFDADLRKM VLRKEKTSLA
     ADSSSFSHAA RQRFFIVKQR AMRCASLKNF KFTTCEILGS STKHLQSVVV LGMLTQQKAD
     CYHIEDLSGS VEVEFKEDTK FHHALFHEHS IAIFEGTFEN SVLTVNEVAM VPVESAEVTR
     KELSSNENWF GGDDKIAFRC SDRLRSALAK QEDTSLVFLS DVFLDDKKVM KAVFKLLQGY
     KDQPPVAIVF CGNFCSRPRQ TDTIDLLDRG FRWLANQLTP LRKDYEKTQF IFVPGPDDPF
     VDTVLPRPHL PSLLFKHISP IISCTFASNP CRIQFASQEI VVFRSDLIKK TCRHSINSIT
     VESIPSRYAR SVLSQAHLCP LPQHITPVLP DFSHSLSLHP LPDLLITADR FETFTEKVVG
     ADTIVSNPGS FSRSNYTFHV YYPCQNRVEA SQIPVSELDD HSNIKNVIIF FFLF