ID   DPOE2_CHICK             Reviewed;         527 AA.
AC   Q5ZKQ6;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA polymerase epsilon subunit 2;
DE   AltName: Full=DNA polymerase II subunit 2;
DE   AltName: Full=DNA polymerase epsilon subunit B;
GN   Name=POLE2; ORFNames=RCJMB04_9k18;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Accessory component of the DNA polymerase epsilon complex (By
CC       similarity). Participates in DNA repair and in chromosomal DNA
CC       replication (By similarity). {ECO:0000250|UniProtKB:P24482,
CC       ECO:0000250|UniProtKB:P56282}.
CC   -!- SUBUNIT: Component of the DNA polymerase epsilon complex consisting of
CC       four subunits: the catalytic subunit POLE and the accessory subunits
CC       POLE2, POLE3 and POLE4. {ECO:0000250|UniProtKB:P56282}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC       beta, gamma, delta, and epsilon which are responsible for different
CC       reactions of DNA synthesis.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ720028; CAG31687.1; -; mRNA.
DR   RefSeq; NP_001006493.1; NM_001006493.1.
DR   AlphaFoldDB; Q5ZKQ6; -.
DR   SMR; Q5ZKQ6; -.
DR   STRING; 9031.ENSGALP00000019955; -.
DR   PaxDb; Q5ZKQ6; -.
DR   Ensembl; ENSGALT00000019982; ENSGALP00000019955; ENSGALG00000012237.
DR   GeneID; 423567; -.
DR   KEGG; gga:423567; -.
DR   CTD; 5427; -.
DR   VEuPathDB; HostDB:geneid_423567; -.
DR   eggNOG; KOG3818; Eukaryota.
DR   GeneTree; ENSGT00390000012435; -.
DR   HOGENOM; CLU_010628_2_0_1; -.
DR   InParanoid; Q5ZKQ6; -.
DR   OMA; CRLQYCT; -.
DR   OrthoDB; 375960at2759; -.
DR   PhylomeDB; Q5ZKQ6; -.
DR   TreeFam; TF103007; -.
DR   Reactome; R-GGA-110314; Recognition of DNA damage by PCNA-containing replication complex.
DR   Reactome; R-GGA-353303; Nucleotide Excision Repair.
DR   Reactome; R-GGA-5656169; Termination of translesion DNA synthesis.
DR   Reactome; R-GGA-5685942; HDR through Homologous Recombination (HRR).
DR   Reactome; R-GGA-5696400; Dual Incision in GG-NER.
DR   Reactome; R-GGA-6782135; Dual incision in TC-NER.
DR   Reactome; R-GGA-68952; DNA replication initiation.
DR   Reactome; R-GGA-68962; Activation of the pre-replicative complex.
DR   PRO; PR:Q5ZKQ6; -.
DR   Proteomes; UP000000539; Chromosome 5.
DR   Bgee; ENSGALG00000012237; Expressed in spermatocyte and 12 other tissues.
DR   ExpressionAtlas; Q5ZKQ6; baseline and differential.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR024639; DNA_pol_e_bsu_N.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708; PTHR12708; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
DR   Pfam; PF12213; Dpoe2NT; 1.
DR   PIRSF; PIRSF000799; DNA_pol_eps_2; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..527
FT                   /note="DNA polymerase epsilon subunit 2"
FT                   /id="PRO_0000071564"
SQ   SEQUENCE   527 AA;  59627 MW;  2A4283B3DF07C2B5 CRC64;
     MEPERLRRRL GSAFRVRGLL LRAEAVKYLT ETLESLNEEE FEDVIDKIID AVEKQPLSTN
     MIELSTVEAA VQECSQALDE TIKNVFNIIG AFDIPRYIYN PDRKRFVPLS MTNLPVPNLF
     GTARDKAELF RERYSILQQR THRHELFTPA AVVIHPDDNR SKFQLKTVET LLGNTAKVRE
     VIVLGMITQL KEGKYFLEDP TGVVQLDLSK AQFHSGLYTE SCFVLAEGWY EDEVFHVNAF
     GFPPTEPSAT TRAFYGNINF FGGPSSASVK ASAKLKQLED ENEDAMFVFL SDVWLDQAEV
     LEKLHTMFSG YSSAPPTCFF FCGNFSSAPY GKNQIQSLKG SLKALADIIC EYPSIHKSSR
     FVFVPGPEDP GPGSVLPRPP LAENITQEFR QLVPFSVFTT NPCRVQYCTQ EIIIFREDLV
     NKMCRNCVRF PSSSMDIPNH FVKTILSQGH LTPLPLYVSP VYWAYDYALR VYPVPDMLVI
     ADKYDPFTVT NTDCLCINPG SFPRSGFSFK VFYPSNKTVE DSKLQGL