ID   DPOE3_DICDI             Reviewed;         138 AA.
AC   Q75JQ9; Q559N6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=DNA polymerase epsilon subunit 3;
DE   AltName: Full=DNA polymerase II subunit 3;
GN   Name=pole3; Synonyms=ybl1; ORFNames=DDB_G0272222;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Accessory component of the DNA polymerase epsilon complex (By
CC       similarity). Participates in DNA repair and in chromosomal DNA
CC       replication (By similarity). Forms a complex with CHRAC1 and binds
CC       naked DNA, which is then incorporated into chromatin, aided by the
CC       nucleosome-remodeling activity of iswi/snf2h and acf1 (By similarity).
CC       {ECO:0000250|UniProtKB:Q04603, ECO:0000250|UniProtKB:Q9NRF9}.
CC   -!- SUBUNIT: Consists of three subunits: pole, pole2 and pole3.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; AAFI02000008; EAL71263.1; -; Genomic_DNA.
DR   RefSeq; XP_645298.1; XM_640206.1.
DR   AlphaFoldDB; Q75JQ9; -.
DR   SMR; Q75JQ9; -.
DR   STRING; 44689.DDB0216318; -.
DR   PaxDb; Q75JQ9; -.
DR   EnsemblProtists; EAL71263; EAL71263; DDB_G0272222.
DR   GeneID; 8618464; -.
DR   KEGG; ddi:DDB_G0272222; -.
DR   dictyBase; DDB_G0272222; ybl1.
DR   eggNOG; KOG0870; Eukaryota.
DR   HOGENOM; CLU_066247_7_2_1; -.
DR   InParanoid; Q75JQ9; -.
DR   OMA; TSCANTH; -.
DR   PhylomeDB; Q75JQ9; -.
DR   Reactome; R-DDI-6782135; Dual incision in TC-NER.
DR   Reactome; R-DDI-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-DDI-68952; DNA replication initiation.
DR   Reactome; R-DDI-68962; Activation of the pre-replicative complex.
DR   PRO; PR:Q75JQ9; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0008623; C:CHRAC; IBA:GO_Central.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0031507; P:heterochromatin assembly; IBA:GO_Central.
DR   GO; GO:0006272; P:leading strand elongation; IBA:GO_Central.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR003958; CBFA_NFYB_domain.
DR   InterPro; IPR009072; Histone-fold.
DR   Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   Coiled coil; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..138
FT                   /note="DNA polymerase epsilon subunit 3"
FT                   /id="PRO_0000328527"
FT   REGION          91..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          79..119
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   138 AA;  15537 MW;  0746E432ECDE928E CRC64;
     MSESQDLPGA IVNRIIKASL PEGVLCAKES RLAIAKAAKV WIHYLTAASI DFSSHSGRST
     ISPKDVFQAI EEIDFENFKP QLEEYLAALK SEKEKEKEKE KEKEKEKEKE KDSNKDDTKS
     KDENKSSKKS SSSSKDEK