ID   DPOE4_BOVIN             Reviewed;         116 AA.
AC   A6QQ14;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA polymerase epsilon subunit 4;
DE   AltName: Full=DNA polymerase II subunit 4;
GN   Name=POLE4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory component of the DNA polymerase epsilon complex (By
CC       similarity). Participates in DNA repair and in chromosomal DNA
CC       replication (By similarity). {ECO:0000250|UniProtKB:P27344,
CC       ECO:0000250|UniProtKB:Q9NR33}.
CC   -!- SUBUNIT: Component of the DNA polymerase epsilon complex consisting of
CC       four subunits: the catalytic subunit POLE and the accessory subunits
CC       POLE2, POLE3 and POLE4. Interaction with POLE3 is a prerequisite for
CC       further binding with POLE and POLE2. {ECO:0000250|UniProtKB:Q9NR33}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BC149592; AAI49593.1; -; mRNA.
DR   RefSeq; NP_001094695.1; NM_001101225.2.
DR   AlphaFoldDB; A6QQ14; -.
DR   SMR; A6QQ14; -.
DR   STRING; 9913.ENSBTAP00000044967; -.
DR   PaxDb; A6QQ14; -.
DR   PRIDE; A6QQ14; -.
DR   Ensembl; ENSBTAT00000047798; ENSBTAP00000044967; ENSBTAG00000017189.
DR   GeneID; 613730; -.
DR   KEGG; bta:613730; -.
DR   CTD; 56655; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017189; -.
DR   VGNC; VGNC:33121; POLE4.
DR   eggNOG; KOG1658; Eukaryota.
DR   GeneTree; ENSGT00940000160888; -.
DR   HOGENOM; CLU_045277_8_0_1; -.
DR   InParanoid; A6QQ14; -.
DR   OMA; HDPDRCG; -.
DR   OrthoDB; 1622159at2759; -.
DR   TreeFam; TF103009; -.
DR   Reactome; R-BTA-68962; Activation of the pre-replicative complex.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000017189; Expressed in thyroid gland and 107 other tissues.
DR   GO; GO:0140672; C:ATAC complex; IEA:Ensembl.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:Ensembl.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR003958; CBFA_NFYB_domain.
DR   InterPro; IPR009072; Histone-fold.
DR   Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..116
FT                   /note="DNA polymerase epsilon subunit 4"
FT                   /id="PRO_0000328528"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   116 AA;  12065 MW;  D6E1A72411F97B55 CRC64;
     MAAAAPGSGA AREEEGTGGD AATPQPPAPT SAPGARLSRL PLARVKALVK ADPDVTLAGQ
     EAIFILARAA ELFVETIAKD AYCCAQQGKR KTLQRRDLDN AIEAVDEFAF LEGTLD