ID   ADEC_META3              Reviewed;         596 AA.
AC   A6UVJ0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=Maeo_0932;
OS   Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS   Nankai-3).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=419665;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA   Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; CP000743; ABR56512.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6UVJ0; -.
DR   SMR; A6UVJ0; -.
DR   STRING; 419665.Maeo_0932; -.
DR   EnsemblBacteria; ABR56512; ABR56512; Maeo_0932.
DR   KEGG; mae:Maeo_0932; -.
DR   eggNOG; arCOG00693; Archaea.
DR   HOGENOM; CLU_027935_0_0_2; -.
DR   OMA; TDHECFT; -.
DR   Proteomes; UP000001106; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..596
FT                   /note="Adenine deaminase"
FT                   /id="PRO_1000068611"
SQ   SEQUENCE   596 AA;  67170 MW;  C2E7DE618CDB7B29 CRC64;
     MIILKNANIV GVRNGTIVNG SIGINGDKIA FVDYIDYNNH NNDNIYNKNE NTQEIRRKQR
     FNTRSEAPVK IIDLKGKFVC PTFIDAHIHI ESSHITPSEF EKYALKYGVS KVIIDPHEIA
     NVVGVNGIKF MLNDAKLLDV YCMVPSCVPA TELETNGAPI TSKDIEELFK QNNYRILGLG
     EVMNYIGVIN KDKNIIDKIN MAKKYNKLID GHAPQLTRED LINYVNMGIM SDHECTTEDE
     ALEKLQLGLK LMVREGTASK NIYLLKIIDI LKRKGTYNKL FKNIMLVSDD ISVKDLKEGY
     LINTLKKAVK YVSPIEAIQM ITINPANYFG LDMEIKPDNY ADLIIFDDLE EFKINSVIIK
     GKFLNELNKY NKNNNIKNNK NNNDNLINKS INYNYKTEND FLIDGIDGGG APISTNSKVR
     IIEPIGSSLI TNEIMLNIDD AKTKLKNNEI NRIFVLERHR NTNKIGKGLI KYLKTGTIAS
     SYAHDSHNVI VIGNNLKDIA IAVNHLKDMG GGFVAVKDGK IIEQVKLNMG GIMGADGEYI
     YKKINDIENK TKNWSIIENN NLFLSMSFLS LSVIPNLKIT DFGLIKNNKI VNLVEL