ID   DPOG2_BOVIN             Reviewed;         485 AA.
AC   Q0VC30;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA polymerase subunit gamma-2, mitochondrial;
DE   AltName: Full=Mitochondrial DNA polymerase accessory subunit;
DE   AltName: Full=MtPolB;
DE   AltName: Full=PolG-beta;
DE   Flags: Precursor;
GN   Name=POLG2; Synonyms=MTPOLB;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial polymerase processivity subunit. It regulates
CC       the polymerase and exonuclease activities promoting processive DNA
CC       synthesis. Binds to ss-DNA. {ECO:0000250|UniProtKB:Q9UHN1}.
CC   -!- SUBUNIT: Heterotrimer composed of a catalytic subunit and a homodimer
CC       of accessory subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
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DR   EMBL; BC120380; AAI20381.1; -; mRNA.
DR   RefSeq; NP_001068659.1; NM_001075191.1.
DR   AlphaFoldDB; Q0VC30; -.
DR   SMR; Q0VC30; -.
DR   STRING; 9913.ENSBTAP00000024509; -.
DR   PaxDb; Q0VC30; -.
DR   PRIDE; Q0VC30; -.
DR   Ensembl; ENSBTAT00000024509; ENSBTAP00000024509; ENSBTAG00000018420.
DR   GeneID; 505152; -.
DR   KEGG; bta:505152; -.
DR   CTD; 11232; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018420; -.
DR   VGNC; VGNC:33123; POLG2.
DR   eggNOG; KOG2298; Eukaryota.
DR   GeneTree; ENSGT00940000153759; -.
DR   HOGENOM; CLU_055833_0_0_1; -.
DR   InParanoid; Q0VC30; -.
DR   OMA; AFREHIF; -.
DR   OrthoDB; 1183820at2759; -.
DR   TreeFam; TF103005; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000018420; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005760; C:gamma DNA polymerase complex; IEA:Ensembl.
DR   GO; GO:0042645; C:mitochondrial nucleoid; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0070182; F:DNA polymerase binding; IEA:Ensembl.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:Ensembl.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:Ensembl.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
DR   GO; GO:0070584; P:mitochondrion morphogenesis; IEA:Ensembl.
DR   GO; GO:1900264; P:positive regulation of DNA-directed DNA polymerase activity; IEA:Ensembl.
DR   GO; GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.
DR   CDD; cd02426; Pol_gamma_b_Cterm; 1.
DR   Gene3D; 3.30.930.10; -; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004154; Anticodon-bd.
DR   InterPro; IPR036621; Anticodon-bd_dom_sf.
DR   InterPro; IPR027031; Gly-tRNA_synthase/POLG2.
DR   InterPro; IPR027030; POLG2.
DR   InterPro; IPR042064; POLG2_C.
DR   PANTHER; PTHR10745; PTHR10745; 1.
DR   PANTHER; PTHR10745:SF8; PTHR10745:SF8; 1.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   SUPFAM; SSF55681; SSF55681; 1.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Mitochondrion; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..485
FT                   /note="DNA polymerase subunit gamma-2, mitochondrial"
FT                   /id="PRO_0000285578"
FT   REGION          28..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   485 AA;  54663 MW;  271DF903661C2C48 CRC64;
     MRSAPAIRAC QRICRCLLSG FGGQVDGRQP EQLSKGTGSF VGPVRSQAEL PRNEPREAPE
     SGGEGSEPLV EICRKRRFLS GTKQQLSRDS LLNGCHPGLG PLGIELRKNL AAEWWSSVVV
     FREQVFPVDA LHREPGPSLP VDNGFRLVSA ETLREILQDK ELSKEQLVAF LENLLNTSGK
     LRENLLHGAL EHYVSYLDLV NKRLPFGLAQ IGACFHPVSD TKQTPDGVKR IGEKTEASLV
     WFTSARTASQ WLDFWLRHRL LWWRKFAMSP SNFSSGDCQD EAGRKGNRLY YNFPWGKEPI
     ETLWNLGDHE LLHMYPGSVA QVHGRDGRKN VVPSVLSING DLDRGMLAYL YDSFQLTENS
     FTRKKDLHRK VLKLHPCLAP IKAALDVGRG PTVELRQVCQ GLFNELLENG ISVWPGYLET
     VQSSLEQLYS KYDEMSILFT VLITEATLEN GLIQLRSRDT TMKEMMHISK VKDFLTKYIS
     SAKNV