ID   DPOG_NEUCR              Reviewed;        1456 AA.
AC   Q9Y767; Q7RV83;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=DNA polymerase gamma, mitochondrial;
DE            EC=2.7.7.7;
DE   AltName: Full=Mitochondrial DNA polymerase catalytic subunit;
DE   Flags: Precursor;
GN   Name=mip-1; Synonyms=pol-g; ORFNames=NCU00276;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RA   Ko T., Seidel-Rogol B.L., Bertrand H.;
RT   "DNA polymerase gamma of Neurospora crassa.";
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in the replication of mitochondrial DNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha,
CC       beta, gamma, delta, and epsilon which are responsible for different
CC       reactions of DNA synthesis.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD21034.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF111068; AAD21034.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CM002238; EAA28511.2; -; Genomic_DNA.
DR   RefSeq; XP_957747.2; XM_952654.3.
DR   AlphaFoldDB; Q9Y767; -.
DR   SMR; Q9Y767; -.
DR   STRING; 5141.EFNCRP00000000196; -.
DR   PRIDE; Q9Y767; -.
DR   EnsemblFungi; EAA28511; EAA28511; NCU00276.
DR   GeneID; 3873917; -.
DR   KEGG; ncr:NCU00276; -.
DR   VEuPathDB; FungiDB:NCU00276; -.
DR   HOGENOM; CLU_001524_1_0_1; -.
DR   InParanoid; Q9Y767; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005760; C:gamma DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IBA:GO_Central.
DR   GO; GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
DR   InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR   InterPro; IPR002297; DNA-dir_DNA_pol_A_mt.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR041336; DNApol_Exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   PANTHER; PTHR10267; PTHR10267; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   Pfam; PF18136; DNApol_Exo; 1.
DR   PRINTS; PR00867; DNAPOLG.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Magnesium;
KW   Mitochondrion; Nucleotidyltransferase; Reference proteome; Transferase;
KW   Transit peptide.
FT   TRANSIT         1..41
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           42..1456
FT                   /note="DNA polymerase gamma, mitochondrial"
FT                   /id="PRO_0000101275"
FT   REGION          1200..1266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1308..1443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1206..1244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1350..1367
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1413..1434
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1456 AA;  161703 MW;  6EB343935F05FC5F CRC64;
     MLTPVRCRTV PNATVATAAR VLRRANLFSR YPRQLGHLRW DSTIAQVLER KGLGVPSTAR
     HNEIGVQQLS EHLYKQLFPR GNTDPPAPEL IELAKDHLAR HDLLGKTTDK TPPIAFQLPA
     LVGDTLDEHF HKLGVDAAEP FLTHAKQFAD AHLPPKPTSW VRRSGWTKYN RDGTTENDVL
     PQGNMMCFDV EVMYKDNPYA VMACAGTPDA WYAWLSPWLL GETENKAQLV PMGDPTVDRI
     IVGHNIGYDR AKILEEYDLK QTRNFFLDTM SLHVAVNGMC SQQRPTWMKH KKARELREKA
     EHESASVELQ EVLQGGSLTA EEADLWVDKS SINSLRDVAQ FHLNVKIDKD IRDVFAETDR
     NVILNQLDDL LTYCAADVQV THQVYQVVFP NFLGVCPHPV SFAALRHLAS VILPVNKTWD
     TYIETAEATY LQMLHGVQER LFTLMERTLD YKADPEKYLS DPWLSQLDWS GQEIKMAKPK
     KKGDVERPAL NQKLPGYPQW YKDLFVKVPK ELSGLDEPDK EQENRKARHE FINLTVRSRI
     APLLLKLSWE GYPLFWSDQF GWTFQVPREK AETFIQRQMT PVQFEDPDVD DRLRMDVDHK
     YFKLPHKDGP NARCVNPMAK GYLPYFEKGI LSSEYPYAKE ALEMNASCSY WISARERIKN
     QMVVYEDQLP PSQRFVNKDA DSNTPIGGFV LPQVIPMGTI TRRAVERTWL TASNAKKNRV
     GSELKAMVRA PPGYVFVGAD VDSEELWIAS VVGDATFKLH GGNAIGFMTL EGTKSQGTDL
     HSRTASILGI TRNDAKVFNY GRIYGAGLKF ASQLLRQFNP SLTEAETTAI ATKLYDATKG
     AKTNRKSLYK RPFWRGGTES FVFNMLEEFA EQERPRTPVL GAGITEALMS RWVSKGGFLT
     SRINWAIQSS GVDYLHLLII AMDYLTRRFN LACRLAITVH DEIRYLAEEP DKYRVAMALQ
     IANLWTRVMF AQQVGIQDLP QSCAFFSAVD IDHVLRKEVD MDCITPSNPI PIAHGESIDI
     FQILEKGDDA KLDDSIVPQS QYAPRLENIP YTPRVPVMQR LRERAEAGDH QAFLRFIRAQ
     ITNSDEELKR IIAETRYSDP YGAFSLASNG RVSGNPHQRH AAVHASTKTA AAPSKPSIAS
     RFDSVSQASR IKSVAAGSDE PTIRATKAQG KAMAKASGTK LAASTKDTVL NVTIKKKVAA
     PEMAAVPSTS SESKSKASAT TSTTTTENAT ASPSSSSNVD AKKTTSKTKP THKKETEGEP
     FPSLDDPVIA ARLEAVSKTS PGTRASVAAK LDALASFSMR AAAAAEAAVT TTTTPEPPTN
     PPPVAPKAKE PTTTMAEKVL KPTAVPKNPT PTLTPTTKKS NPTSTPTTPK PVGRPRTTPI
     LPYTAPKKKL PSSAFSKEQK EPMSVSEAVW TASVGGRATT TTATATATGD EKKKTTTTPS
     WKPVKESLFG RGVYIP