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DPOL1_SULOH
ID   DPOL1_SULOH             Reviewed;         872 AA.
AC   O50607;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=DNA polymerase 1;
DE            EC=2.7.7.7;
DE   AltName: Full=DNA polymerase B1;
DE   AltName: Full=DNA polymerase I;
GN   Name=pol-alpha;
OS   Sulfurisphaera ohwakuensis.
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfurisphaera.
OX   NCBI_TaxID=69656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TA-1;
RX   PubMed=10997874; DOI=10.1093/dnares/7.4.243;
RA   Iwai T., Kurosawa N., Itoh Y.H., Kimura N., Horiuchi T.;
RT   "Sequence analysis of three family B DNA polymerases from the
RT   thermoacidophilic crenarchaeon Sulfurisphaera ohwakuensis.";
RL   DNA Res. 7:243-251(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; AB008894; BAA23994.1; -; Genomic_DNA.
DR   PIR; JC7380; JC7380.
DR   AlphaFoldDB; O50607; -.
DR   SMR; O50607; -.
DR   BRENDA; 2.7.7.7; 13316.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..872
FT                   /note="DNA polymerase 1"
FT                   /id="PRO_0000046487"
SQ   SEQUENCE   872 AA;  100932 MW;  D4A4B5F44CB5B7E5 CRC64;
     MARQITLFDF TLKKEQNKDE SRKEEIPHAN INEERRKPKE WIKEAEEGKS YFLLQVDYDG
     KKSKAICKLY DKETKKIYIL YDNTGHKPYF LTDIDPEKVN KIPKVVRDPS FDHLETVIKI
     DPYSGNKIKL TKIVVKDPLA VRRMRNSVPK AYEAHIKYFN NYIYDLGLIP GLPYVVKKGK
     LEQLRPELKG EEVDEIRKAF ADSDEMTKEA VNDWIPIFES EVPDVKRVAI DIEVYTPIKG
     RIPDPEKAEF PIISISLAGN DGTKRVLVLL REDVNSQITK HDVIVETFKS ERELIRRFFD
     IILDYPIILT FNGDDFDIPY IYYRALKLNF TPEEIPFDII NDEGKYLAGI HIDLYKFFFN
     RAIRNYAFEG KYNEYNLDAV ATALLGMSKV KLDTLISFLD LDKLIEYNSR DAEITLKLTT
     FNNNLVWKLI ILLARISKMG LEELTRTEVS TWIKNLYYWE HRRRNWLIPL KEEILTRSSQ
     IKTAAIIKGK RYKGAVVIDP PAGVFFNVVV LDFASLYPSI IRNWNISYET VDVENCKNKE
     YVRDETGEVL HYICKDKPGI TAVITGLLRD FRVKVYKKKA KSQNISEEQR SVYDVVQRAM
     KVFINATYGV FGAENFPLYA PAVAESVTAI GRYVITTTVN YCRSIGLQVL YGDTDSMFLW
     NPSKEKLEEI IKFVKGKFGL DLEVDKVYKF VAFSGLKKNY LGVYPDGKTD IKGMLAKKRN
     TPEFIKKEFN EVKQLVTTIN SPDDIPKIRD QLEYKIKEIY EKLRHKGYNL DELAFRVMLS
     KPLESYTKNT PQHVKAALQL RSYGVMVLPR DIIMFVKVKS KDGVKPVQLA KLSEIDVDKY
     IDAVRSTFEQ ILKAFGLIGA NLLQLLSILS LT
 
 
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