DPOL1_SULOH
ID DPOL1_SULOH Reviewed; 872 AA.
AC O50607;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=DNA polymerase 1;
DE EC=2.7.7.7;
DE AltName: Full=DNA polymerase B1;
DE AltName: Full=DNA polymerase I;
GN Name=pol-alpha;
OS Sulfurisphaera ohwakuensis.
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfurisphaera.
OX NCBI_TaxID=69656;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=TA-1;
RX PubMed=10997874; DOI=10.1093/dnares/7.4.243;
RA Iwai T., Kurosawa N., Itoh Y.H., Kimura N., Horiuchi T.;
RT "Sequence analysis of three family B DNA polymerases from the
RT thermoacidophilic crenarchaeon Sulfurisphaera ohwakuensis.";
RL DNA Res. 7:243-251(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR EMBL; AB008894; BAA23994.1; -; Genomic_DNA.
DR PIR; JC7380; JC7380.
DR AlphaFoldDB; O50607; -.
DR SMR; O50607; -.
DR BRENDA; 2.7.7.7; 13316.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.10; -; 1.
DR Gene3D; 3.90.1600.10; -; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR SUPFAM; SSF56672; SSF56672; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW Nucleotidyltransferase; Transferase.
FT CHAIN 1..872
FT /note="DNA polymerase 1"
FT /id="PRO_0000046487"
SQ SEQUENCE 872 AA; 100932 MW; D4A4B5F44CB5B7E5 CRC64;
MARQITLFDF TLKKEQNKDE SRKEEIPHAN INEERRKPKE WIKEAEEGKS YFLLQVDYDG
KKSKAICKLY DKETKKIYIL YDNTGHKPYF LTDIDPEKVN KIPKVVRDPS FDHLETVIKI
DPYSGNKIKL TKIVVKDPLA VRRMRNSVPK AYEAHIKYFN NYIYDLGLIP GLPYVVKKGK
LEQLRPELKG EEVDEIRKAF ADSDEMTKEA VNDWIPIFES EVPDVKRVAI DIEVYTPIKG
RIPDPEKAEF PIISISLAGN DGTKRVLVLL REDVNSQITK HDVIVETFKS ERELIRRFFD
IILDYPIILT FNGDDFDIPY IYYRALKLNF TPEEIPFDII NDEGKYLAGI HIDLYKFFFN
RAIRNYAFEG KYNEYNLDAV ATALLGMSKV KLDTLISFLD LDKLIEYNSR DAEITLKLTT
FNNNLVWKLI ILLARISKMG LEELTRTEVS TWIKNLYYWE HRRRNWLIPL KEEILTRSSQ
IKTAAIIKGK RYKGAVVIDP PAGVFFNVVV LDFASLYPSI IRNWNISYET VDVENCKNKE
YVRDETGEVL HYICKDKPGI TAVITGLLRD FRVKVYKKKA KSQNISEEQR SVYDVVQRAM
KVFINATYGV FGAENFPLYA PAVAESVTAI GRYVITTTVN YCRSIGLQVL YGDTDSMFLW
NPSKEKLEEI IKFVKGKFGL DLEVDKVYKF VAFSGLKKNY LGVYPDGKTD IKGMLAKKRN
TPEFIKKEFN EVKQLVTTIN SPDDIPKIRD QLEYKIKEIY EKLRHKGYNL DELAFRVMLS
KPLESYTKNT PQHVKAALQL RSYGVMVLPR DIIMFVKVKS KDGVKPVQLA KLSEIDVDKY
IDAVRSTFEQ ILKAFGLIGA NLLQLLSILS LT