ID   DPOL3_SACS2             Reviewed;         764 AA.
AC   P95979;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=DNA polymerase 3;
DE            EC=2.7.7.7;
DE   AltName: Full=DNA polymerase B3;
DE   AltName: Full=DNA polymerase III;
GN   Name=dpo3; OrderedLocusNames=SSO0081; ORFNames=C04041, C05_029;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=8899719; DOI=10.1111/j.1365-2958.1996.tb02666.x;
RA   Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y.,
RA   Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F.,
RA   Ragan M.A., Charlebois R.L.;
RT   "Organizational characteristics and information content of an archaeal
RT   genome: 156 kb of sequence from Sulfolobus solfataricus P2.";
RL   Mol. Microbiol. 22:175-191(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
RN   [3]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=9098062; DOI=10.1128/jb.179.8.2632-2640.1997;
RA   Edgell D.R., Klenk H.-P., Doolittle W.F.;
RT   "Gene duplications in evolution of archaeal family B DNA polymerases.";
RL   J. Bacteriol. 179:2632-2640(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; Y08257; CAA69570.1; -; Genomic_DNA.
DR   EMBL; AE006641; AAK40441.1; -; Genomic_DNA.
DR   PIR; S75407; S75407.
DR   RefSeq; WP_009988892.1; NC_002754.1.
DR   AlphaFoldDB; P95979; -.
DR   SMR; P95979; -.
DR   STRING; 273057.SSO0081; -.
DR   EnsemblBacteria; AAK40441; AAK40441; SSO0081.
DR   GeneID; 44129042; -.
DR   KEGG; sso:SSO0081; -.
DR   PATRIC; fig|273057.12.peg.80; -.
DR   eggNOG; arCOG00328; Archaea.
DR   HOGENOM; CLU_000203_6_0_2; -.
DR   InParanoid; P95979; -.
DR   OMA; FVLTRHW; -.
DR   PhylomeDB; P95979; -.
DR   BRENDA; 2.7.7.7; 6163.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IBA:GO_Central.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 2.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..764
FT                   /note="DNA polymerase 3"
FT                   /id="PRO_0000046486"
SQ   SEQUENCE   764 AA;  88379 MW;  1A4325C7D9A4D672 CRC64;
     MIKDFFILDF SYEIKGNTPL VYIWSVDDEG NSSVVIDNNF RPYFYIIYEG NENEIIENIK
     KNCEALQITK VKRKYLGNIV DALLIQTSTP TQIKKCREKI SELNNIKGIF DADIRYTMRY
     SLDFDLRPFT WFRAEVNEVK FDGFRTKKAY ILDKILSHYE GNMPELRTIG VDFQIYSKYG
     SLNPRKDPIV VMSLWSKEGP MQFSLDEGID DLKIIRRFVD YILNYDPDII FVYDSDLLPW
     KYITERASSL GVKIDIGRKI GSEVSVGTYG HYSISGRLNV DLTGLLVNER SLGHVDLIDV
     SNYLGISPSR YSFKWYEISR YWDNEKNRRI IREYSIENAR SIYLLGNYLL STYSELVKIV
     GLPLDKLSVA SWGNRIETSL IRTATKSGEL IPIRMDNPNR PSKIKKNIII QPKVGIYTDV
     YVLDISSVYS LVIRKFNIAP DTLVKEQCDD CYSSPISNYK FKREPSGLYK TFLDELSNVR
     DSNKIKVIEE LISSFNDYVH WVNARWYSRE IASAFDEFSN EIIRFIIDLI KSSGLDVILA
     NDLLIFVTGG SRDKVNELIT KINSLYNLDV KVKIFYKSLL VLDNNRYAGL SEGDKIDIAR
     KGEEDMNLCE LARNIKRKII EEILISKDVK KAIKLVKSTV IKLRRGEFDN EELITWAKIE
     RDLNEYNNQL PFVTAARKAI QSGYLISKDS KIGYVIVKGL GPLNDRAEPF FLVKEKNRID
     IEYYVDQIFR ETLKLLKPLG VNEESLKKTN ITDILDLFGA SKKK