ID   ADEC_METJA              Reviewed;         556 AA.
AC   Q58854;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=MJ1459;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; L77117; AAB99467.1; -; Genomic_DNA.
DR   PIR; B64482; B64482.
DR   AlphaFoldDB; Q58854; -.
DR   SMR; Q58854; -.
DR   STRING; 243232.MJ_1459; -.
DR   EnsemblBacteria; AAB99467; AAB99467; MJ_1459.
DR   KEGG; mja:MJ_1459; -.
DR   eggNOG; arCOG00693; Archaea.
DR   HOGENOM; CLU_027935_0_0_2; -.
DR   InParanoid; Q58854; -.
DR   OMA; TDHECFT; -.
DR   PhylomeDB; Q58854; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IBA:GO_Central.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..556
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000142440"
SQ   SEQUENCE   556 AA;  62623 MW;  06BD5E31E7EF5EFD CRC64;
     MIVFKNTKII DVYTGEVVKG NVAVERDKIS FVDLNDEIDK IIEKIKEDVK VIDLKGKYLS
     PTFIDGHIHI ESSHLIPSEF EKFVLKSGVS KVVIDPHEIA NIAGKEGILF MLNDAKILDV
     YVMLPSCVPA TNLETSGAEI TAENIEELIL LDNVLGLGEV MNYPAVINED EEMLKKIEVA
     KKYNKLIDGH CPKLKGWELN KYISHGIMSD HESVDEDEAL EKLRLGLKLM IREGTASKNI
     YLLNICKKIK DFRNIMLVSD DVCIKDLDGY MLNILRKATN YVSPIEAIQM VTINPANYFG
     FDVGIKAGNE ASFVIFEDLD NFKVYNIVIK GRFLDDVLNE LNKNKKRKIP EKLMNTLKYQ
     YKNEGDFLIK GIDYKERDGF IRVIKPLKDS LITEELIFST EEIKILLNEN AINKIFVIER
     HKNTGNIGKG LIYNFLEEGA LASSYAHDSH NVIAIGNNEK DLALAVNKLK DIGGGFIAAK
     DGEVVEYLPL PVGGIMGDDG KYIAEKINAL YKKIEGWSSF ENPFLSMSFF SLPVIPELKI
     TDKGLVKDMQ LVDLFI