ID   ADEC_METKA              Reviewed;         599 AA.
AC   Q8TX47;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC;
GN   OrderedLocusNames=MK0829;
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=190192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; AE009439; AAM02042.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TX47; -.
DR   SMR; Q8TX47; -.
DR   STRING; 190192.MK0829; -.
DR   PRIDE; Q8TX47; -.
DR   EnsemblBacteria; AAM02042; AAM02042; MK0829.
DR   KEGG; mka:MK0829; -.
DR   HOGENOM; CLU_027935_0_0_2; -.
DR   OMA; TDHECFT; -.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..599
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000142441"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   599 AA;  65401 MW;  2978B26973FFB877 CRC64;
     MARSNRRGGR GDPEDDPAWA PPGHRCAGER AVGGPTVIPR AYLPAVPAGG NESRAFQGRF
     VDPWFSGIRT GYVIWDGGRL LGVTRNEPEH ADVIDVDGII CPGFVDAHVH VESSGLRPAR
     YAEIVVREGT TAVVWDPHEV VNVSGELGLE WAVKTAEEAL PFKFYIALPS CVPALGPPYE
     TVEGEITVDV ARKFASHPMV VSVGELMDVA GVMEGEKDEF IELKSLYGLT VDGHAPGLTG
     FEAMRYFAAG PETDHECSTA EEFTSRRELG VWTFVRQGSS SKDMEVALET LEDLRGVCFV
     TDDLHVKDMD EISLRKIVGR AIEAGFDPLE SLSAVTLNPS LCYGLQSGRL VPGFHADIVV
     VEDLDENMEL TDVWIGGKRS ERVRFRDAEA ELPDVELSVD PREVSFQDGK YEVRCVGLVR
     GSIRTEEIVR EITVKDGAVK DDDVAFLVVT DRYGQGSWSI GFVEGFEELD CAVVSTVAHD
     SHNVVVAGRR LDDVRRALQL VSEVGGCVGA VAGDRAEFVR LDVAGLMSSS DPEEVKKSYE
     DVLELIRSSS GVDWDPFQAL SFVTLPVVPE LRLTDRGLVK VEPDEIRFVD IITDGDPVE