ID   DPOLX_MIMIV             Reviewed;         354 AA.
AC   Q7T6Y4;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 2.
DT   23-FEB-2022, entry version 92.
DE   RecName: Full=Probable DNA polymerase family X;
DE            EC=2.7.7.7;
GN   OrderedLocusNames=MIMI_L318;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=16971431; DOI=10.1128/jvi.00940-06;
RA   Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H.,
RA   Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D.;
RT   "Mimivirus giant particles incorporate a large fraction of anonymous and
RT   unique gene products.";
RL   J. Virol. 80:11678-11685(2006).
CC   -!- FUNCTION: Repair polymerase. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:16971431}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-X family. {ECO:0000305}.
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DR   EMBL; AY653733; AAQ09576.2; -; Genomic_DNA.
DR   RefSeq; YP_003986821.1; NC_014649.1.
DR   SMR; Q7T6Y4; -.
DR   GeneID; 9924935; -.
DR   KEGG; vg:9924935; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00141; NT_POLXc; 1.
DR   Gene3D; 1.10.150.110; -; 1.
DR   Gene3D; 3.30.210.10; -; 1.
DR   Gene3D; 3.30.460.10; -; 1.
DR   InterPro; IPR002054; DNA-dir_DNA_pol_X.
DR   InterPro; IPR019843; DNA_pol-X_BS.
DR   InterPro; IPR010996; DNA_pol_b-like_N.
DR   InterPro; IPR028207; DNA_pol_B_palm_palm.
DR   InterPro; IPR018944; DNA_pol_lambd_fingers_domain.
DR   InterPro; IPR027421; DNA_pol_lamdba_lyase_dom_sf.
DR   InterPro; IPR037160; DNA_Pol_thumb_sf.
DR   InterPro; IPR022312; DNA_pol_X.
DR   InterPro; IPR002008; DNA_pol_X_beta-like.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR029398; PolB_thumb.
DR   PANTHER; PTHR11276; PTHR11276; 1.
DR   Pfam; PF14792; DNA_pol_B_palm; 1.
DR   Pfam; PF14791; DNA_pol_B_thumb; 1.
DR   Pfam; PF10391; DNA_pol_lambd_f; 1.
DR   Pfam; PF14716; HHH_8; 1.
DR   PRINTS; PR00869; DNAPOLX.
DR   PRINTS; PR00870; DNAPOLXBETA.
DR   SMART; SM00483; POLXc; 1.
DR   SUPFAM; SSF47802; SSF47802; 1.
DR   SUPFAM; SSF81301; SSF81301; 1.
DR   PROSITE; PS00522; DNA_POLYMERASE_X; 1.
PE   1: Evidence at protein level;
KW   DNA damage; DNA repair; DNA replication; DNA synthesis; DNA-binding;
KW   DNA-directed DNA polymerase; Lyase; Nucleotidyltransferase;
KW   Reference proteome; Transferase; Virion.
FT   CHAIN           1..354
FT                   /note="Probable DNA polymerase family X"
FT                   /id="PRO_0000218799"
SQ   SEQUENCE   354 AA;  40612 MW;  BF25ACE5AA6244E5 CRC64;
     MNSKIIEQFN LLEKQVDAEY LNSKVENDLK EETMNRFRLK SIKKALSILK NLDFEITDAN
     DVKGIPGIGA GTIKRIKEIL ETGKLHDLKD KFSPEKQKQI EGIQELENVI GIGSSTAKKL
     ISQYGIRSVD DLKKAIETGK VKVSTSIMLG LKYYGIVQRD IPRKEITAIE KLLSKEAHKI
     DPDLEIIICG SYRRGKKTSG DIDVLMYHPK MKTSKEMLHP EKFDLEPYFN LYIDRLTEKG
     FLIDDITFNP NKKYMGFCKY KLNPVRRIDI RFIPYNSLAP AMLYFTGPME LNTKMRSAAK
     KRKMILNEYG LFKTDKNGAQ IPLDTKSEAD IFHALGMDYL TPQQRELYSS GKIH