ID   DPOL_ABVP               Reviewed;         653 AA.
AC   A4ZU91; A4ZU92;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   23-FEB-2022, entry version 66.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   ORFNames=ORF653;
OS   Acidianus bottle-shaped virus (isolate Italy/Pozzuoli) (ABV).
OC   Viruses; Ampullaviridae; Bottigliavirus; Bottigliavirus ABV.
OX   NCBI_TaxID=654911;
OH   NCBI_TaxID=269667; Acidianus convivator.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17412384; DOI=10.1016/j.virol.2007.03.005;
RA   Peng X., Basta T., Haring M., Garrett R.A., Prangishvili D.;
RT   "Genome of the Acidianus bottle-shaped virus and insights into the
RT   replication and packaging mechanisms.";
RL   Virology 364:237-243(2007).
CC   -!- FUNCTION: Replicates viral genomic DNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=DNA polymerase;
CC         IsoId=A4ZU91-1; Sequence=Displayed;
CC       Name=ORF462;
CC         IsoId=A4ZU91-2; Sequence=VSP_038084;
CC   -!- MISCELLANEOUS: [Isoform ORF462]: Produced by alternative initiation of
CC       the DNA polymerase mRNA. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABP73395.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; EF432053; ABP73396.1; -; Genomic_DNA.
DR   EMBL; EF432053; ABP73395.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_001210309.1; NC_009452.1.
DR   RefSeq; YP_001210310.1; NC_009452.1.
DR   GeneID; 5129850; -.
DR   GeneID; 5129855; -.
DR   KEGG; vg:5129850; -.
DR   KEGG; vg:5129855; -.
DR   Proteomes; UP000000513; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   Pfam; PF03175; DNA_pol_B_2; 1.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; DNA replication; DNA-binding;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Reference proteome;
KW   Transferase; Viral DNA replication.
FT   CHAIN           1..653
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000384817"
FT   VAR_SEQ         1..191
FT                   /note="Missing (in isoform ORF462)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_038084"
SQ   SEQUENCE   653 AA;  76864 MW;  54170AF0C026F0A7 CRC64;
     MLQILNNAND KIQYKLNDFS DLTPSFKIKS GFFTIHRINY EKLEENEEEK PRQISAFDIE
     TNGREIFFGV YDGSEYKYVI IRKPEDVKNA LDLLTEETYF YGDYDLPVSL ANYVLLGKHS
     KFAKKITGEN YFTTKNLRIK RYKNFYKILY NGRSINSINL LQFYSESLYE AYSRYYTKLQ
     EMGFQVFDEQ TMKEWKEDKE KRANFDKLDF NDPKTIQEIA RYNKLDVIAT YQLALLKNSL
     FGIKVKSTLP RTAITYIISQ VQSEFVKGLR SYTEIELTLK RLYKGGLFDS NELGKFKKVY
     KYDVNSMYPF MMSWLPELEL VETQKGFEVN EEPLLKGTQF NEDAKYVYIY KITLKQDRKY
     VASKANGMLL RMMYNRGSFF DFELADEKHE LIPDIKIVGQ YYTMKFKITK HRIFKDVIYN
     LYNKRLQLKK EKNPLEKVYK LILNSSYGKF GERIGFNAKF QNVIYASMIT ALGRTFIQNV
     DPNAISYLTD SVISKAPIKS ELVGDQLGQL KQEGVGEAIV IGNGQYILND PQEKMIKLRG
     FNVDESIAEK IIEYVGNYLA KGKIVRVQIP TKIMIRNLQQ YKILAEKDSN VLMGMLSNQI
     KIFTPLNTKQ RYTYNVHWFG SMFRDEQEHK EYRKTWEKYI ETIEPIDLNS ILS