ID   DPOL_ALHV1              Reviewed;        1026 AA.
AC   O36363;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   23-FEB-2022, entry version 110.
DE   RecName: Full=DNA polymerase catalytic subunit;
DE            EC=2.7.7.7;
GN   Name=9;
OS   Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Macavirus.
OX   NCBI_TaxID=654901;
OH   NCBI_TaxID=9927; Connochaetes taurinus (Blue wildebeest).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9261371; DOI=10.1128/jvi.71.9.6517-6525.1997;
RA   Ensser A., Pflanz R., Fleckenstein B.;
RT   "Primary structure of the alcelaphine herpesvirus 1 genome.";
RL   J. Virol. 71:6517-6525(1997).
CC   -!- FUNCTION: Replicates viral genomic DNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF005370; AAC58060.1; -; Genomic_DNA.
DR   PIR; T03108; T03108.
DR   RefSeq; NP_065512.1; NC_002531.1.
DR   SMR; O36363; -.
DR   PRIDE; O36363; -.
DR   GeneID; 911748; -.
DR   KEGG; vg:911748; -.
DR   Proteomes; UP000000941; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   Coiled coil; DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Host nucleus; Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1026
FT                   /note="DNA polymerase catalytic subunit"
FT                   /id="PRO_0000405694"
FT   COILED          664..695
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1026 AA;  116255 MW;  C6211A5B65A9CEDC CRC64;
     MMCFFFFSLQ PCLFKLPLPL PLKKNTAMLS FWNPYLRGFK APTPATKSKP KASTIYHRLI
     PKCFKKDERE NGGIFAIETA IPPTAFYLDS ELLVLPENKS SLWANETLGN CHSIQELMFH
     VYDIVEVVYA ADRCDSIPPH LQADIVPSGI VLKLYGRTET NQSVCVNVFG QKVYFYVYND
     SYSNLQRDVQ HILQETGHRS TGLHLCSTQK KFLSGYSTSS HEVYQITLGS SSAMRSLASG
     LEQIGYRVFE ANVDASTRFI VDNKFSTFGW YTCTSPLARP RVHQDAHTHL EYDCSVGDIQ
     YHAERLDWPQ YNILSFDIEC LGESGFPSAD KDEDMIIQIS CVIWTVGGDK KQECILLSVG
     TCDLIENVKV YEFPSEMDLL YGFFTLLRDY GIEMITGYNI CNFDFPYILN RAQNVYNIKP
     EDFSKTKTNS LFYVYTPQEG NFMRSHSKVK MSGVVVIDMY QVCRDKLNLS NYKLNTVAKE
     CLGEKKNDVS YKDIPILFKG SSKDRAKLGM YCVQDAVLVI DLLKHFMTHI EITEIAKIAN
     IPTRRVLSDG QQIRVFTCLL AAAQERDYIL PMPVTGSQEG YQGATVINPI SGFYNTPVLV
     VDFASLYPSI IQAHNLCYST LIKQQDLPKF TNLTANDYET FMISGGPVHF VKKHKTESLL
     ASLLKTWLAK RKSIKKELEQ CQDAKMKTIL DKQQLAIKVT CNSVYGFTGV ASGMLPCLMI
     AETVTLQGRT MLEKTKQFVE NVTVEYLQKI CNFEVQCLPQ HPNPKFRVVY GDTDSLFIKC
     EGFAMDTVIK FGDALASHTS SVLFASPIKL ESEKVFKCLM LLTKKRYVGI LSNNKILMKG
     VDLVRKTACV YVQEVTRAVL ELLLRDEEVK VAAQTLSYSP VANCFKTEPL LGFLKIIDIL
     NQSYSDLKSN KVPVANLTYS TELSKPFTEY KTTNLPHLAV YKKLAMRNEE LPQIHDRISY
     VFVKSNGHLV SDMAEDPTYA EQNKIPIASD WYFDKIIHGV ANILQCVFNN NTSATVEVLY
     NFVRNP