ID   DPOL_ARCFU              Reviewed;         781 AA.
AC   O29753;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=pol; Synonyms=polB; OrderedLocusNames=AF_0497;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; AE000782; AAB90741.1; -; Genomic_DNA.
DR   PIR; A69312; A69312.
DR   RefSeq; WP_010878004.1; NC_000917.1.
DR   AlphaFoldDB; O29753; -.
DR   SMR; O29753; -.
DR   STRING; 224325.AF_0497; -.
DR   PRIDE; O29753; -.
DR   EnsemblBacteria; AAB90741; AAB90741; AF_0497.
DR   GeneID; 24794037; -.
DR   KEGG; afu:AF_0497; -.
DR   eggNOG; arCOG00328; Archaea.
DR   HOGENOM; CLU_000203_6_0_2; -.
DR   OMA; GNQKSPY; -.
DR   OrthoDB; 35869at2157; -.
DR   PhylomeDB; O29753; -.
DR   BRENDA; 2.7.7.7; 414.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..781
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000046476"
SQ   SEQUENCE   781 AA;  89851 MW;  761C7B18FCC61B8B CRC64;
     MERVEGWLID ADYETIGGKA VVRLWCKDDQ GIFVAYDYNF DPYFYVIGVD EDILKNAATS
     TRREVIKLKS FEKAQLKTLG REVEGYIVYA HHPQHVPKLR DYLSQFGDVR EADIPFAYRY
     LIDKDLACMD GIAIEGEKQG GVIRSYKIEK VERIPRMEFP ELKMLVFDCE MLSSFGMPEP
     EKDPIIVISV KTNDDDEIIL TGDERKIISD FVKLIKSYDP DIIVGYNQDA FDWPYLRKRA
     ERWNIPLDVG RDGSNVVFRG GRPKITGRLN VDLYDIAMRI SDIKIKKLEN VAEFLGTKIE
     IADIEAKDIY RYWSRGEKEK VLNYARQDAI NTYLIAKELL PMHYELSKMI RLPVDDVTRM
     GRGKQVDWLL LSEAKKIGEI APNPPEHAES YEGAFVLEPE RGLHENVACL DFASMYPSIM
     IAFNISPDTY GCRDDCYEAP EVGHKFRKSP DGFFKRILRM LIEKRRELKV ELKNLSPESS
     EYKLLDIKQQ TLKVLTNSFY GYMGWNLARW YCHPCAEATT AWGRHFIRTS AKIAESMGFK
     VLYGDTDSIF VTKAGMTKED VDRLIDKLHE ELPIQIEVDE YYSAIFFVEK KRYAGLTEDG
     RLVVKGLEVR RGDWCELAKK VQREVIEVIL KEKNPEKALS LVKDVILRIK EGKVSLEEVV
     IYKGLTKKPS KYESMQAHVK AALKAREMGI IYPVSSKIGY VIVKGSGNIG DRAYPIDLIE
     DFDGENLRIK TKSGIEIKKL DKDYYIDNQI IPSVLRILER FGYTEASLKG SSQMSLDSFF
     S