ID   DPOL_ASFWA              Reviewed;        1199 AA.
AC   P0C973;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=DNA polymerase beta;
DE            EC=2.7.7.7 {ECO:0000250|UniProtKB:P42489};
GN   OrderedLocusNames=War-100;
OS   African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561444;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-directed DNA polymerase involved in viral DNA
CC       replication. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: Consistent with its intracellular location, ASFV encodes
CC       its own replicative DNA polymerase and three base excision repair
CC       enzymes: a class II AP endonuclease, the repair polymerase Pol X, and
CC       an ATP-dependent DNA ligase.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; AY261366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C973; -.
DR   Proteomes; UP000000858; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Early protein;
KW   Nucleotidyltransferase; Transferase; Viral DNA replication.
FT   CHAIN           1..1199
FT                   /note="DNA polymerase beta"
FT                   /id="PRO_0000373072"
SQ   SEQUENCE   1199 AA;  138641 MW;  B2B897B7EAB6E3BF CRC64;
     MDRSEIVARE NPVITQRVTN LLQTNAPLLF MPIDIHEVRY GAYTLFMYGS LENGYKAEVR
     IENIPVFFDV QIESSNTNQL FLKSLLTAEN ITYERLETLT QRPVMGYREK EKEFAPYIRI
     FFKSLYERRK AITYLNNMGY NTAADDTTCY YRMVSRELKL PLTSWIQLQH YSYEPHGLVH
     RFSVTPEDLV SYQDDGPTDH SIVMAYDIET YSPVKGTVPD PNQANDVVFM ICMRIFWIHS
     TEPLASTCIT MAPCKKSSEW TTILCSSEKN LLLSFAEQFS RWAPDICTGF NDSRYDWPFI
     VEKSMQHGIL EEIFNKMSLF WHQKLDTILK CYYVKEKRVK ISAEKSIISS FLHTPGCLPI
     DVRNMCMQLY PKAEKTSLKA FLENCGLDSK VDLPYHLMWK YYETRDSEKM ADVAYYCIID
     AQRCQDLLVR HNVIPDRREV GILSYTSLYD CIYYAGGHKV CNMLIAYAIH DEYGRIACST
     IARGKREHGK YPGAFVIDPV KGLEQDKPTT GLDFASLYPS LIMAYNFSPE KFVASREEAN
     SLMAKGESLH YVSFHFNNRL VEGWFVRHNN VPDKMGLYPK VLIDLLNKRT ALKQELKKLG
     EKKECIHESH PGFKELQFRH AMVDAKQKAL KIFMNTFYGE AGNNLSPFFL LPLAGGVTSS
     GQYNLKLVYN FVINKGYGIK YGDTDSLYIT CPDSLYTEVT DAYLNSQKTI KHYEQLCHEK
     VLLSMKAMST LCAEVNEYLR RDNGTSYLRM AYEEVLFPVC FTGKKKYYGI AHVNTPNFNT
     KELFIRGIDI IKQGQTKLTK TIGTRIMEES MKLRRPEDHR PPLIEIVKTV LKDAVVNMKQ
     WNFEDFIQTD AWRPDKDNKA VQIFMSRMHA RREQLKKHGA AASQFAEPEP GERFSYVIVE
     KQVQFDIQGH RTDSSRKGDK MEYVSEAKAK NLPIDILFYI NNYVLGLCAR FINENEEFQP
     PDNVSNKDEY AQRRAKSYLQ KFVQSIHPKD KSVIKQGIVH RQCYKYVHQE IKKKIGIFAD
     LYKEFFNNTT NPIESFIQST QFMIQYFDGE QKVNHSMKKM VEQHATSAGN SAGNPAGNAL
     MRAIFTQLIT EEKKIVQALY NKGDAIHDLL TYIINNINYK IATFQTKQML TFEFSSTHVE
     LLLKLNKTWL ILAGIHVAKK HLQALLDSYN NEPPSRTFIQ QAIEEECGSI KPSCYDFIS