ID   DPOL_BPCP1              Reviewed;         568 AA.
AC   Q37989;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 103.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
DE            EC=3.1.11.- {ECO:0000250|UniProtKB:P03680};
GN   Name=5;
OS   Streptococcus phage Cp-1 (Bacteriophage Cp-1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Salasmaviridae; Cepunavirus.
OX   NCBI_TaxID=10747;
OH   NCBI_TaxID=1313; Streptococcus pneumoniae.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7645213; DOI=10.1006/viro.1995.1375;
RA   Martin A.C., Lopez R., Garcia P.;
RT   "Nucleotide sequence and transcription of the left early region of
RT   Streptococcus pneumoniae bacteriophage Cp-1 coding for the terminal protein
RT   and the DNA polymerase.";
RL   Virology 211:21-32(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8648702; DOI=10.1128/jvi.70.6.3678-3687.1996;
RA   Martin A.C., Lopez R., Garcia P.;
RT   "Analysis of the complete nucleotide sequence and functional organization
RT   of the genome of Streptococcus pneumoniae bacteriophage Cp-1.";
RL   J. Virol. 70:3678-3687(1996).
CC   -!- FUNCTION: Replicates the viral genomic DNA. This polymerase possesses
CC       two enzymatic activities: DNA synthesis (polymerase) and an
CC       exonucleolytic activity that degrades single-stranded DNA in the 3'- to
CC       5'-direction for proofreading purpose. {ECO:0000250|UniProtKB:P03680}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- MISCELLANEOUS: This DNA polymerase requires a protein as a primer.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; Z47794; CAA87725.1; -; Genomic_DNA.
DR   PIR; S51275; S51275.
DR   RefSeq; NP_044817.1; NC_001825.1.
DR   SMR; Q37989; -.
DR   IntAct; Q37989; 1.
DR   PRIDE; Q37989; -.
DR   GeneID; 1261225; -.
DR   KEGG; vg:1261225; -.
DR   Proteomes; UP000009089; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0001882; F:nucleoside binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR   InterPro; IPR014416; DNA-dir_DNA_polB_phi29_vir.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF03175; DNA_pol_B_2; 2.
DR   PIRSF; PIRSF004178; Dpol_Bac_phage; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease;
KW   Hydrolase; Nuclease; Nucleotidyltransferase; Reference proteome;
KW   Transferase; Viral DNA replication.
FT   CHAIN           1..568
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000046541"
SQ   SEQUENCE   568 AA;  66149 MW;  515F5EAEF1897896 CRC64;
     MTCYYAGDFE TTTNEEETEV WLSCFAKVID YDKLDTFKVN TSLEDFLKSL YLDLDKTYTE
     TGEDEFIIFF HNLKFDGSFL LSFFLNNDIE CTYFINDMGV WYSITLEFPD FTLTFRDSLK
     ILNFSIATMA GLFKMPIAKG TTPLLKHKPE VIKPEWIDYI HVDVAILARG IFAMYYEENF
     TKYTSASEAL TEFKRIFRKS KRKFRDFFPI LDEKVDDFCR KHIVGAGRLP TLKHRGRTLN
     QLIDIYDINS MYPATMLQNA LPIGIPKRYK GKPKEIKEDH YYIYHIKADF DLKRGYLPTI
     QIKKKLDALR IGVRTSDYVT TSKNEVIDLY LTNFDLDLFL KHYDATIMYV ETLEFQTESD
     LFDDYITTYR YKKENAQSPA EKQKAKIMLN SLYGKFGAKI ISVKKLAYLD DKGILRFKND
     DEEEVQPVYA PVALFVTSIA RHFIISNAQE NYDNFLYADT DSLHLFHSDS LVLDIDPSEF
     GKWAHEGRAV KAKYLRSKLY IEELIQEDGT THLDVKGAGM TPEIKEKITF ENFVIGATFE
     GKRASKQIKG GTLIYETTFK IRETDYLV