ID   DPOL_BPSPB              Reviewed;        1305 AA.
AC   O64146;
DT   04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   23-FEB-2022, entry version 85.
DE   RecName: Full=DNA-directed DNA polymerase;
DE            EC=2.7.7.7 {ECO:0000305};
OS   Bacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Spbetavirus.
OX   NCBI_TaxID=66797 {ECO:0000312|Proteomes:UP000009091};
OH   NCBI_TaxID=1408; Bacillus pumilus (Bacillus mesentericus).
OH   NCBI_TaxID=1423; Bacillus subtilis.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9465078; DOI=10.1073/pnas.95.4.1692;
RA   Lazarevic V., Soldo B., Duesterhoeft A., Hilbert H., Maueel C.,
RA   Karamata D.;
RT   "Introns and intein coding sequence in the ribonucleotide reductase genes
RT   of Bacillus subtilis temperate bacteriophage SPbeta.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:1692-1697(1998).
CC   -!- FUNCTION: Replicates viral genomic DNA. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. {ECO:0000305}.
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DR   EMBL; AF020713; AAC13106.1; -; Genomic_DNA.
DR   PIR; T12897; T12897.
DR   RefSeq; NP_046685.1; NC_001884.1.
DR   SMR; O64146; -.
DR   GeneID; 1261476; -.
DR   KEGG; vg:1261476; -.
DR   Proteomes; UP000009091; Genome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.1600; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1305
FT                   /note="DNA-directed DNA polymerase"
FT                   /id="PRO_0000431826"
SQ   SEQUENCE   1305 AA;  150538 MW;  B4E4E694C807D1C0 CRC64;
     MIGCHCHTDR SNIRLLDSTN SVKELLKTAV KMEYKGLAIT DHEVLSAHLD AIRTVREMKK
     KGDMPEDFKL ILGNEAYLVD SLEEVRDNYK SGVTKFPHFL MLAMDPKGHE QLRILSSQAW
     ENSFYTGTME RVPTVKKDVE ELLSKDPGHI IATTACLGSE VNIHLLKIKA FEETGDSQSI
     KQHKLKIHEF ITWCIEVFGK DKFFIELQPA LSEEQIYCNK KLIDIANGYD LQMIVTTDAH
     YLRPEDRAIH QAFLNAKDGE REVDSFYEAC FVQNVDEIHE RMDYIDKEVI DQAIKNTMLI
     GEMIEDYTIE HEPIIPKMEL PNFKLRHLFK PAYDQYEYIK KMSESADEQD RYLLKLIEDG
     FEEKLKTSEL TREAFHKILN RINVELGELW EISQKLNQSM SSYYITVREI INIIWDDECG
     GDSLVGAARG SAAGYLVNYL LDNTQINPMQ YDLPHWRHIH KSRPDLPDID IDTEGSKRQK
     ILKALRERFG DKRVLQIATF GTEGSKSALQ TACRGLGIDN DISQYLSGMI PFERGSNWPL
     KHCFYGDKET GRKPIKEFIR EVEQYPNLKE TALKIEGLTN KRSSHAAGVI IFNDEYTKSN
     AMMKTPKGAY ITQFNMGDSE AMGSVKFDLL TIEALDKIRV TLDQLIENNE IEWQGSLKET
     YNKYIHPDVI EYEDDKLWEM AGNGEIMDLF QFSTEVGHQS VVKVKPKNLL EAAVTNSLMR
     LMSDGEEQPV DTYVKYKNNL NKWYEEMTRY GLSEKEIRVM ERHLKDIYGV ADTQEVVMQM
     VMDKDIANFD IKESNYLRKS IAKKKEDVLK EVEELFFKKG KEIGTSDNLL NYVWNVQFKR
     QFGYSFSLLH TLAYSIIALQ ELNLNYRYNP LYWNTACLTV NSGGIDTEDT KDNKKTAATN
     YGKVASAIGN IRQRGIKIDL PDINKADFGF RTDINNNSIL FGLKGMNGIG DDVIHHIVLN
     RPYSDFNDFI ERMFKSGIIK KGQVIQLIKG GCFDSFGNRQ EIMKAFISLI SEPKSKLTLS
     NLKMLIENNI VPSEFAQEVR FFRFKDYISK KVYKTLKSPK DKLFLLDDVS ASFYNQHFSE
     DSVVDMLNGQ LVISEKAFKK EYDNKMSNIK SWITTEEPLK KLNDCLLIKE WEKYADGSLG
     KWEMDSLSYY YNDHELSGVN FAKYDIADFY KLPAEPVKGK PYQWRGKTLY EYETTRIIGT
     VLDRDKNKHA ITLLTPTGVV TVKQWSGSFS HYNKQISRSI GGGKKEVIEK SWYTRGTLLM
     FTGFRRGNNF IPKVYKDSIY NHTVCRIDFV DNEGSMSLTT KRAEI