ID   DPOL_CBEPV              Reviewed;         964 AA.
AC   P30319;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   23-FEB-2022, entry version 85.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=POL;
OS   Choristoneura biennis entomopoxvirus (CbEPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Entomopoxvirinae; Betaentomopoxvirus.
OX   NCBI_TaxID=10288;
OH   NCBI_TaxID=7141; Choristoneura fumiferana (Spruce budworm moth) (Archips fumiferana).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1840516; DOI=10.3109/10425179109008437;
RA   Mustafa A., Yuen L.;
RT   "Identification and sequencing of the Choristoneura biennis entomopoxvirus
RT   DNA polymerase gene.";
RL   DNA Seq. 2:39-45(1991).
CC   -!- FUNCTION: Catalyzes DNA synthesis. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; X57314; CAA40566.1; -; Genomic_DNA.
DR   PIR; S25855; S25855.
DR   SMR; P30319; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR013617; DNA-dir_DNA_pol_B_vir_insert.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF08408; DNA_pol_B_3; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Transferase; Viral DNA replication.
FT   CHAIN           1..964
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000046537"
SQ   SEQUENCE   964 AA;  114819 MW;  F8FF5AC957363A68 CRC64;
     MKLKKLYIFY FDIYEYFLCD LQLSETNEIL KYIKNNIDKY TNSFNSSYII LKDFNIITNE
     VELQSYYNFT EDSKIKLNNT DLILFMTPYK IERIYSKYNR NFNQYRWFYI LNNIEPAGSY
     KINMSNLQNI NIYDKNKTAY YCKNPKLLFL TPIEIDKFIP VSRVSIDIEC QHFGEFPTPN
     KFPISHICID WFMESNINPV KKIITLINYE IIKNYKGEQK DRFIYTEIDE LLTKDKVYIT
     IYCTEKYMLH FILYTLRKDF DYILTYNGHS FDFTYIQGRR KFYNLNELCL VNAHKSNELK
     IYSYNKDTTY EIDSNNGIIF LDLYNYIKKI YNYNSYKLGE IAKERFNILS KIIDNGDEYI
     IMPLDTADNK NKVSIFYDVI RTANYCFINN IPYKIKDKTK IINDKEKLYD PISIENSLYQ
     QFKIYKNNTP ISDETTKVML SKDDVDIGNK NAYVNFTKDK SDDIAYYCTH DTVLCNCIFK
     YDMIHDKVIA FSNEYLLPQY MSFKYKSTTN ISGLLLKTLF CNRSMIVSGN LEFEKFEGGY
     VLEPKQKYID SITAVFDFNS EYPSNIIEAN LSPEKVEKVI KLQDDEYAVD IVENYLKEKY
     PYPDYCYMLI KKDKTYKFIV MDRRKPGIIT QMIDKGMKSK NEYKNLKNIN KNNPVLYNYY
     TSALYSKKIT INSLYGLLGS ERFDFNSPYC AEYCTALGQK CIKYIKNLVD KSRYIDNNLY
     LNEQNNPFSN EPVITRYSGN LDVNFTFYII YGDTDSLFIN IKFDNKFDNK EDLVNKSHEC
     FQFLSNIIND EKNIILSKNF NFEYEKMYIW MLLLAKKKYI GEVVSSMNPL QLISDSKGTA
     LIRRDCTEIH KTILKNTIDI LKEYLTNNCT IQDVNNKINN YLMFTFKNII ENIQNLDINE
     FKKSVKYTGI YKDPNFYIEL CVKKYNSKNP NDKIVKGQRF DFIYAHEIDI WDIETKKWNT
     KYTS