ID   DPOL_EHV2               Reviewed;        1008 AA.
AC   P52367;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   29-SEP-2021, entry version 100.
DE   RecName: Full=DNA polymerase catalytic subunit;
DE            EC=2.7.7.7;
GN   Name=9;
OS   Equine herpesvirus 2 (strain 86/87) (EHV-2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Percavirus.
OX   NCBI_TaxID=82831;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7783207; DOI=10.1006/jmbi.1995.0314;
RA   Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus 2.";
RL   J. Mol. Biol. 249:520-528(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U20824; AAC13796.1; -; Genomic_DNA.
DR   PIR; S55603; S55603.
DR   RefSeq; NP_042605.1; NC_001650.2.
DR   SMR; P52367; -.
DR   PRIDE; P52367; -.
DR   GeneID; 1461085; -.
DR   KEGG; vg:1461085; -.
DR   Proteomes; UP000007083; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Host nucleus;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1008
FT                   /note="DNA polymerase catalytic subunit"
FT                   /id="PRO_0000046520"
SQ   SEQUENCE   1008 AA;  112664 MW;  252604AC9D03AB0F CRC64;
     MSFYNPYLVK RTFLKKAAPS RPTKEYTRII PKCFKTPGAA GVVPHTSTLD PVCFVGDKET
     PILYGDGSRS LWSAGGRGGP GTGAGQGHTP VALTFHVYDI IETVYGQDRC DHVPFQFQTD
     IIPSGTVLKL LGRTSDDRSV CVNVFRQELY FYVRVPEGLK LDFLIQQCSR ENFNFSQGRY
     RYEKTSKRVL REYCVEAREV YRVFASSQGF VDLLAGGLTA AGCEVFETNV DAARRFIIDN
     GFSTFGWYSC AAAVPRQGGA ARDSWTELEY DCAAGDLEFH AGRADWPGYN VLSFDIECLG
     ENGFPNASRD EDMILQISCV IWKAGSGEAP RSVLLNLGTC EEIEGVEVYQ CPSELDLLYL
     FFTMIRDADV EFVTGYNISN FDFPYVIDRA TQVYNLNLKE FTRVRSSSIF EVHKPKNSSA
     GFMRAVSKVK VAGVVPIDMY QVCRDKLSLS NYKLDTVAGE CVGAKKEDVS YKEIPHLFRQ
     GPGGRARLGL YCVKDSALVL DLLRYFMTHV EISEIAKIAK IPTRRVLTDG QQIRVFSCLL
     DVAGREGYIL PVDRHADAEG YQGATVIDPS PGFYNTPVLV VDFASLYPTI IQAHNLCYST
     MIPGDRLCLH PHLGPGDYET FELASGPVHF VKKHKAVSLL ATLLNVWLAK RKAIRRELAT
     VSDEAVRTIL DKQQLAIKVT CNAVYGFTGV ASGILPCLKI AETVTFQGRR MLENSKRYIE
     GVTPEGLADI LGRRVECAPD ASFKVIYGDT DSLFIHCRGY RPEQVTGFCD ELAAHMTRTL
     FVDPIKLEAE KTFKCLILLT KKRYIGMMTT DRLLMKGVDL VRKTACRFVQ ETTKAILDLV
     MGDEAVRAAA ERLCAMRVEE VCARGPPVGF LKVVDILNDS YRKLRLNRVP VGQLSFSTEL
     SRPISYYKTL TLPHLVVYHK IMQRNEELPQ IHDRIAYVFV QSPKGKLRSE MAEDPAYAAQ
     HNIPPAVDLY FDKVIHGAAN ILQCLFENDS DKAARVLYNF ADLPPDDL