ID   DPOL_FRG3G              Reviewed;        1013 AA.
AC   Q6GZR5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 80.
DE   RecName: Full=Putative DNA polymerase 060R;
DE            EC=2.7.7.7;
GN   ORFNames=FV3-060R;
OS   Frog virus 3 (isolate Goorha) (FV-3).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Alphairidovirinae; Ranavirus.
OX   NCBI_TaxID=654924;
OH   NCBI_TaxID=30343; Dryophytes versicolor (chameleon treefrog).
OH   NCBI_TaxID=8404; Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OH   NCBI_TaxID=45438; Lithobates sylvaticus (Wood frog) (Rana sylvatica).
OH   NCBI_TaxID=8316; Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15165820; DOI=10.1016/j.virol.2004.02.019;
RA   Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.;
RT   "Comparative genomic analyses of frog virus 3, type species of the genus
RT   Ranavirus (family Iridoviridae).";
RL   Virology 323:70-84(2004).
CC   -!- FUNCTION: DNA-directed DNA polymerase involved in viral DNA
CC       replication. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; AY548484; AAT09720.1; -; Genomic_DNA.
DR   RefSeq; YP_031639.1; NC_005946.1.
DR   SMR; Q6GZR5; -.
DR   GeneID; 2947760; -.
DR   KEGG; vg:2947760; -.
DR   Proteomes; UP000008770; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 2.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1013
FT                   /note="Putative DNA polymerase 060R"
FT                   /id="PRO_0000410575"
SQ   SEQUENCE   1013 AA;  114479 MW;  E04293DC0B271FDE CRC64;
     MDLFVYQWFC DGSQEIRAYA VDSDSSTVCV RVTGFRPGFY VETASCQAVT RALQDFRDVS
     AEKRVRDHLY ATRGSSVPFV WVTFRCWFDA RKASDVLVKA GFACHQCRAQ PVLQLTSLRD
     LPTCGWIRLG KGAVQVKREK YSRCKREFIV QWEQVERGPD VPQPEVTVVA LDLEVNSEVE
     NAMPKDRPGD EVFMAGAIIL RPGKKPKRVL LSLEADDYPE AEVLAERGYA VQQYPNERSL
     ISGLCDMLSS VKPQVVTGYN VLGFDIDYLL KRCVRLGMEE ELCLTGMAAE RPAKERTISW
     SSSAFGAQKY SYLDWEGVVA VDLLPIIKRD YKFDSYRLDF VTETLLGSNK DPVTAADIFR
     AYATRKMDVV GEYCVKDVQL CVDLMEKLQV WVGLTEMAKV CRVNAFTLFT QGQQIRIYSQ
     VYCHCEKNGY VVTDPADGKR VPWGQDPPVS DEPDEDYIGA HVVEPSPGIY DNVVPLDFSS
     LYPSIMIAKN VCYSTRVDPG TPGSETFTWE DHLNCVHDPR KVEYERLSSE LWDLDSEARE
     LRRERDAIPR KRVDDRRLVV DTLNTVLDAQ RMLRTTRAAL KNQLGTKTVC ACRLLAFLEP
     ATKKGVMPTI LTDLLDGRKR AKKAKAEAKD SITKITMDKR QLAYKVSANS MYGAMGVKRG
     YLPFQDGAMT VTYFGRQCIE KAASIIGSEH GGQLVYGDTD SNYVTFADAK TPAELWDKAV
     AVAKAVSSVF PPPISLEFEQ VIYTKFLILG KKRYIYLSCD RDGNSSGKMG FRGVLMARRD
     NSGLARKAYS ITAQALLEDR DPWADLTPLM KDMYTKNCSL RDFVITKQVG SWCRECAFIE
     QGADSIVAVG DYKIRDLEKA KAETRKITGT DGGPEYMAVL YKLVMAQLPG HVQLANRMIG
     RGETVADGTR LEYVVLRPSY DGKKRRFRGQ GLSERLETSD YYKRFAEFLE LDTEHYVKTL
     VNPLDQLLTT AGRPEDEFKA FYGYRVNYRK VVEDIKTLRA CPEMVKIVSF KKK