ID   ADEC_METTH              Reviewed;         538 AA.
AC   O26952;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Adenine deaminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000255|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000255|HAMAP-Rule:MF_01518}; OrderedLocusNames=MTH_866;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR   EMBL; AE000666; AAB85364.1; -; Genomic_DNA.
DR   PIR; F69215; F69215.
DR   RefSeq; WP_010876499.1; NC_000916.1.
DR   AlphaFoldDB; O26952; -.
DR   SMR; O26952; -.
DR   STRING; 187420.MTH_866; -.
DR   EnsemblBacteria; AAB85364; AAB85364; MTH_866.
DR   GeneID; 1471274; -.
DR   KEGG; mth:MTH_866; -.
DR   PATRIC; fig|187420.15.peg.850; -.
DR   HOGENOM; CLU_027935_0_0_2; -.
DR   OMA; TDHECFT; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11113:SF2; PTHR11113:SF2; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..538
FT                   /note="Adenine deaminase"
FT                   /id="PRO_0000142443"
SQ   SEQUENCE   538 AA;  57884 MW;  8F50FC50D55A367D CRC64;
     MISGNILNVF TGDIYPAEIE VAGGRVRCVR SISGNFSDII IPGFIDAHLH IESSMLIPSS
     FAAAAIPHGT VSAISDPHEI ANVMGVDGVR FMIDDAAATP MKFYFTAPSC VPATPFETAG
     AEITARGIEE LLRMDSVVAL GEMMNFPAVI AGDDGVMAKI KAARDLNMPV DGHAPLLSGD
     ELCTYIGAGI STDHECVSPE EVLEKRRLGM KIMAREGSSA RNLRDLAAAG CDFLVSDDIH
     PADLLEGHMD RILRRAVDYG IDPVSAVQMV TINPAEHYGL STGAIAPGWD ADFVVVDSLR
     DFNVKRVYID GRPVADRGRY LIRRSGGTRA PPRKLEVPDF PVERLNIRAE GDEATVRVID
     VLDGQLITEE LIATLEVEDG TVQADTSSDI LRVSVLDRYG RGNISSGFVH GFGLQEGAIA
     STVAHDSHNL IVVGVDPELM KRAVDILKKA GGGLVAVSGD DHRVLQLPVA GLMSDGDVFE
     VADGFENLNT FTEQLGSRLS APFMTMSFLS LLVIPRLKIG DRGLFDVEKF EIKNLMEM