ID   DPOL_HHV6U              Reviewed;        1012 AA.
AC   P28857; Q69061;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   23-FEB-2022, entry version 110.
DE   RecName: Full=DNA polymerase catalytic subunit;
DE            EC=2.7.7.7;
GN   Name=U38; Synonyms=XILF0;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1651403; DOI=10.1128/jvi.65.9.4670-4680.1991;
RA   Teo I.A., Griffin B.E., Jones M.D.;
RT   "Characterization of the DNA polymerase gene of human herpesvirus 6.";
RL   J. Virol. 65:4670-4680(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 778-1012.
RX   PubMed=8289364; DOI=10.1128/jvi.68.2.597-610.1994;
RA   Nicholas J., Martin M.E.D.;
RT   "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome
RT   of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene
RT   homologs and transactivating functions.";
RL   J. Virol. 68:597-610(1994).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; M63804; AAA74631.1; -; Genomic_DNA.
DR   EMBL; X83413; CAA58372.1; -; Genomic_DNA.
DR   EMBL; L25528; AAA16745.1; -; Genomic_DNA.
DR   PIR; B40898; DJBE6S.
DR   RefSeq; NP_042931.1; NC_001664.2.
DR   SMR; P28857; -.
DR   BindingDB; P28857; -.
DR   ChEMBL; CHEMBL4009; -.
DR   PRIDE; P28857; -.
DR   GeneID; 1487916; -.
DR   KEGG; vg:1487916; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Host nucleus;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1012
FT                   /note="DNA polymerase catalytic subunit"
FT                   /id="PRO_0000046516"
SQ   SEQUENCE   1012 AA;  115820 MW;  A9CB0BC3DC98731B CRC64;
     MDSVSFFNPY LEANRLKKKS RSSYIRILPR GIMHDGAAGL IKDVCDSEPR MFYRDRQYLL
     SKEMTWPSLD IARSKDYDHM RMKFHIYDAV ETLMFTDSIE NLPFQYRHFV IPSGTVIRMF
     GRTEDGEKIC VNVFGQEQYF YCECVDGRSL KATINNLMLT GEVKMSCSFV IEPADKLSLY
     GYNANTVVNL FKVSFGNFYV SQRIGKILQN EGFVVYEIDV DVLTRFFVDN GFLSFGWYNV
     KKYIPQDMGK GSNLEVEINC HVSDLVSLED VNWPLYGCWS FDIECLGQNG NFPDAENLGD
     IVIQISVISF DTEGDRDERH LFTLGTCEKI DGVHIYEFAS EFELLLGFFI FLRIESPEFI
     TGYNINNFDL KYLCIRMDKI YHYDIGCFSK LKNGKIGISV PHEQYRKGFL QAQTKVFTSG
     VLYLDMYPVY SSKITAQNYK LDTIAKICLQ QEKEQLSYKE IPKKFISGPS GRAVVGKYCL
     QDSVLVVRLF KQINYHFEVA EVARLAHVTA RCVVFEGQQK KIFPCILTEA KRRNMILPSM
     VSSHNRQGIG YKGATVLEPK TGYYAVPTVV FDFQSLYPSI MMAHNLCYST LVLDERQIAG
     LSESDILTVK LGDETHRFVK PCIRESVLGS LLKDWLAKRR EVKAEMQNCS DPMMKLLLDK
     KQLALKTTCN SVYGVTGAAH GLLPCVAIAA SVTCLGREML CSTVDYVNSK MQSEQFFCEE
     FGLTSSDFTG DLEVEVIYGD TDSIFMSVRN MVNQSLRRIA PMIAKHITDR LFKSPIKLEF
     EKILCPLILI CKKRYIGRQD DSLLIFKGVD LVRKTSCDFV KGVVKDIVDL LFFDEEVQTA
     AVEFSHMTQT QLREQGVPVG IHKILRRLCE AREELFQNRA DVRHLMLSSV LSKEMAAYKQ
     PNLAHLSVIR RLAQRKEEIP NVGDRIMYVL IAPSIGNKQT HNYELAEDPN YVIEHKIPIH
     AEKYFDQIIK AVTNAISPIF PKTDIKKEKL LLYLLPMKVY LDETFSAIAE VM