ID   DPOL_HHV6Z              Reviewed;        1012 AA.
AC   Q9QJ32;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   23-FEB-2022, entry version 102.
DE   RecName: Full=DNA polymerase catalytic subunit;
DE            EC=2.7.7.7;
GN   Name=U38;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- FUNCTION: Replicates viral genomic DNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; AF157706; AAD49652.1; -; Genomic_DNA.
DR   RefSeq; NP_050219.1; NC_000898.1.
DR   SMR; Q9QJ32; -.
DR   PRIDE; Q9QJ32; -.
DR   GeneID; 1497040; -.
DR   KEGG; vg:1497040; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Host nucleus;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1012
FT                   /note="DNA polymerase catalytic subunit"
FT                   /id="PRO_0000408402"
SQ   SEQUENCE   1012 AA;  115669 MW;  7A46A699970E3D10 CRC64;
     MDSVSFFNPY LEANRLKKKS RSSYIRILPR GIMHDGAAGL IKDVCDSEPR MFYRDRQYLL
     SKEMTWPSLD RVRSKDYDHT RMKFHIYDAV ETLMFTDSIE NLPFQYRHFV IPSGTVIRMF
     GRSEDGEKIC VNVFGQEQYF YCECVDGKSL KATINNLMLT GEVKMSCSFV IEPADKLSLY
     GYNANTVVNL FKVSFGNFYV SQRIGKILQN EGFVVYEIDV DVLTRFFVDN GFLSFGWYNV
     KKYIPQDMGK GSNLEVEINC HVSDLVSLEN VNWPLYGCWS FDIECLGQNG NFPDAENLGD
     IVIQISVVSF DTEGDRDERH LFTLGTCEQI DGVHIYEFAS EFELLLGFFI FLRIESPEFI
     TGYNINNFDL KYLCIRMDKI YHYEIGCFSK LKNGKIGISV PHEQYKKGFL QAQTKVFTSG
     VLYLDMYPVY SSKITAQNYK LDTIAKICLQ QEKEQLSYKE IPKKFISGPS GRAVVGKYCL
     QDSVLVVRLF KQINYHYEVA EVARLAHVTA RCVVFEGQQK KIFPCILTEA KRRNMILPSM
     VSSHNRQGIG YKGATVLEPK TGYYAVPTVV FDFQSLYPSI MMAHNLCYST LVLDERQIAG
     LSESDILTVK LGDETHRFVK PCVRESVLGS LLKDWLAKRR EVKAEMQNCS DPMMKLLLDK
     KQLALKTTCN SVYGVTGAAH GLLPCVAIAA SVTCLGREML CSTVDYVNSK MQSEQFFCEE
     LGLTASDFTG DLKVEVIYGD TDSIFMSVRN MANESLRRIA PMIAKHITDR LFKSPIKLEF
     EKILCPLILI CKKRYIGRQD DSLLIFKGVD LVRKTSCDFV KGVVKDIVDL LFFDEEVQTA
     AVEFSHMTQT QLREQGVPVG IHKILRRLCK AREELFQNRA DVRHLMLSSV LSKEVAAYKQ
     PNLAHLSVIR RLAQRKEEIP NVGDRIMYVL IAPSTGNKQT HNYELAEDPN YVLEHKIPIH
     AEKYFDQIIK AVTNAISPIF PKTDIKKEKL LLYLLPMKVY LDETFSAIAE VM