ID   DPOL_HHV7J              Reviewed;        1012 AA.
AC   P52342;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 105.
DE   RecName: Full=DNA polymerase catalytic subunit;
DE            EC=2.7.7.7;
GN   Name=U38;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; U43400; AAC54700.1; -; Genomic_DNA.
DR   PIR; T41940; T41940.
DR   SMR; P52342; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Host nucleus;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1012
FT                   /note="DNA polymerase catalytic subunit"
FT                   /id="PRO_0000046517"
SQ   SEQUENCE   1012 AA;  115764 MW;  EB75D1AD5C293FB5 CRC64;
     MDLVSFFNPY LENVRTKKKT KSTFLRIFPR GIMHDGAPGL MKTLCDSEPR MFYQDKQYIL
     KNDMTWPSLS QVAEKELRAP LKFHIYDASE SLLFTDSIEN IPFQYRHFVI PSGNVIKLFG
     KTECGKKVCI NVFGQNSYFY CEYQCKKELN SRICSLLNSS EIKMSCSFSI ESVTKYNFYG
     YNTEPIKNLF KLSFSNFYIS NRIGKILLNE GVSVYEAEVE ILNRFFIDNN LKSFGWYQIN
     YLSIQEFAKS SNVEIELNCH VSDLFLLKED SWPLYDCCSF DIECLSQNGN FPDAEQMVTS
     SLISVIDFDS EGNYQSKHLF TLGTCEQIEG VFIYEFASEF ELLYAFFLFL KCKSPEILTG
     YNIINFDLKY LCTRMEKIYN FEIGGFSKLK RGKFSVIVPY EQHKKFLNSL TKVNMSGILC
     FDMYNVYSSK ISAQNYKLDT IAKLCLNQEK ENLSYKEIPK KFIDGSKGRA VVGRYCIQDS
     LLVVQLFTKI NYHYEMAEVA SLAYITIRCA VFEGQQKKIF PCILHEAKNL NMILPSMNTN
     FNKGKENVGY KGATVLEPKI GYYATPTVVF DFQSLYPSIM MAHNLCYSTL VVDENAVIGL
     HADDILTVHV GPVTHRFVKK TVRESILASL LKKWLDKRKE VKMQMKMCNN PVMEMLLDKK
     QLALKTTCNS VYGVTGATHS LLPCVAIAAS VTCLGREMLC KTVDYVDSAM YSDTFFIEKF
     GLTRGDFSGT FGIEVIYGDT DSLFVTFKNV CPKALKRIAP SIASHITNTL FKHPIKLEFE
     KILFPLILIC KKRYIGKLDD ATLVFKGVEL VRKTSCDFVK VVVKDIIDLL FWDVDVQKSA
     EKLSNMTIQE IYENGVPDGI QKIIKKLCDA RDALFLNRVN IKSLVLSSVL SKDISAYKQA
     NLPHLAVVKR LAQRKEELPN IGDRVMYILI APTETVKKTF HNYELAEDPA YAIENNLKIN
     ADKYFEQIMK AVTNAISPIF PKTGIKKEKF LLSILPLKVY VDQSFCDLTD VL