ID   DPOL_HIS1I              Reviewed;         717 AA.
AC   Q25BI3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   29-SEP-2021, entry version 44.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
OS   His1 virus (isolate Australia/Victoria) (His1V) (Haloarcula hispanica virus
OS   1).
OC   Viruses; Halspiviridae; Salterprovirus; Salterprovirus His1.
OX   NCBI_TaxID=654912;
OH   NCBI_TaxID=51589; Haloarcula hispanica.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16530800; DOI=10.1016/j.virol.2006.02.005;
RA   Bath C., Cukalac T., Porter K., Dyall-Smith M.L.;
RT   "His1 and His2 are distantly related, spindle-shaped haloviruses belonging
RT   to the novel virus group, Salterprovirus.";
RL   Virology 350:228-239(2006).
CC   -!- FUNCTION: Replicates viral genomic DNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; AF191796; AAQ13724.1; -; Genomic_DNA.
DR   RefSeq; YP_529524.1; NC_007914.1.
DR   GeneID; 5142394; -.
DR   KEGG; vg:5142394; -.
DR   Proteomes; UP000007024; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   Pfam; PF03175; DNA_pol_B_2; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..717
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000384870"
SQ   SEQUENCE   717 AA;  81938 MW;  6433444A6ADC7141 CRC64;
     MAKCDKSLEA IDLDRAYTAP RKAKWAENKR INGLDTETSD GDIFCISVCW EGEKPMVQHN
     DREKLTSKQV WQVLTDHKAR SSLNMWYNLD FDANVVLNHV CSEEQLAELV VSGTTLANSD
     RTYRQYMDTD KELRKGEYLI TYIQSKFLEI KDHNSHIYTH YDASQFFYTS LENAVTEWLG
     ESKANDGLEA GLFGSQTPNQ LRETVAESDC VTWTNLSLTY NVSKGDKWTI HNAKSYISKN
     WSDILKYAQI DAELVRDLWQ EAVNVGEELD IPMGRPFSTG YLAESYLDNR LREKPGLGPM
     PMAKMAWESY AGGRFEVLKR GNVGRVAGPD INSAYPAVLA ELPDPKTLRW KRAKHASISE
     IETADYGFMT VKVSTDPTRE IQPFAVKDEK QDKLVYPSPQ NTEITVVKDI FIHAYNQGYV
     TDYEVIDCWL GYKTEGTTFP FDFIPELYDN RKTAEANGLE KRGLLLKIVL NSMYGKTCQT
     TPKRRELAES TELELHESYV PDMSLPKMIR EKYSEGFIES LTAGAWFNPF LASYITGLTR
     LELHKQICKH DLEENTVMLA TDCVMIEEKP FEESNFVENL VQDGLGYWDM EYKGDAFVLG
     AGVYQIDFDT CQKGCKDNCN KFSHKHKVKT RGFSEADLEK GLVNAAEKAN GHIEIESTRP
     QTISEIIWSN EELSQVGNFL EQERKIKPEM DTKRKWSENT DFKKLLSTCE TSLPLKI