ID   DPOL_HVAVE              Reviewed;        1086 AA.
AC   A4KX57;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   23-FEB-2022, entry version 59.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   ORFNames=ORF1;
OS   Heliothis virescens ascovirus 3e (HvAV-3e).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Ascoviridae; Ascovirus.
OX   NCBI_TaxID=260797;
OH   NCBI_TaxID=7100; Noctuidae (owlet moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17374755; DOI=10.1099/vir.0.82651-0;
RA   Asgari S., Davis J., Wood D., Wilson P., McGrath A.;
RT   "Sequence and organization of the Heliothis virescens ascovirus genome.";
RL   J. Gen. Virol. 88:1120-1132(2007).
CC   -!- FUNCTION: Replicates the viral genome. Host DNA polymerases cannot
CC       substitute for the viral enzyme in this process (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; EF133465; ABO37187.1; -; Genomic_DNA.
DR   RefSeq; YP_001110854.1; NC_009233.1.
DR   SMR; A4KX57; -.
DR   GeneID; 5076078; -.
DR   KEGG; vg:5076078; -.
DR   Proteomes; UP000001324; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 2.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1086
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000329070"
FT   REGION          638..657
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        639..656
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1086 AA;  123797 MW;  F3C4C2EC12E904C0 CRC64;
     MDSITNGESF YVYDWRVVST EKDTNYFDRS GNRKKWTEIT LMLRAYCVDA NGATVCLRMG
     QVKTKLYVEF PENYDLNPRR WSAIRTILKD AIYCKNDKCD SNIQRVSLQP LYGAKQVRTY
     VAIEFTSEVG KRAFINKISG KCDQRTKRTS AKFPDNVTGD QLRFHWMNVP TELQVLVNAK
     LPFAGWIETG RLYSPKDRKT RCDREYSVDI KQVRTSTSMA CVTPPLKTFA WDIEAKINDM
     SSPGTHEDDE VYMISISVSD NTDHLILIAP DGCGEAMKRS MGAGDELTVH VCPNEVSLLL
     EFNKVCRSIG AVARMGWNVN RFDCVVLMAR ANRLNCSTTL LDLGLALDVP GCVSTTAGRT
     FGRFSPNDAI YFDTHGVLCL DVMEMFKSTY TKLPKYSLQY VSQKFLGTTK DPVTLKDLNE
     LHSRLMLDDD HTNALRAVVS KYCVVDSRLT LQLCQKCAHM TSLTEMARIT NTPITMVHYQ
     KQQRRMFHLM FSECARKGVA MQDDFGRDRR LTMLDEDSTD GSSNVDNKRQ LNYSGAYVKD
     PEPGLYNMVG SLDVNSMYPT LMIAYNLCYS TVIDDDAHSD YTDENFEIVE WEDHVGCEHD
     PNIKEREKLK SIFEDLAKVE KRKFIGVQPI TKYFKPTSTT RKPVDDVEEH SECNGFTDDN
     YNDSPVSSIK LSSVDLQRAA IRLKVLKSRM SGGSKLCAKQ RVRILKTRRG LLPDLVEYFL
     DARRKVRAEM KNVSDPLARD ILDKSQLAYK VTANSVYGST GAVNGKLPCQ NVAKVTTALG
     RKTILQSIDI AQRDRSVSTI YSDTDSMYVQ LGDEAGDDPW KFVRELAAHI TSKLRKPMVI
     EAEDDIHAKV LFLGKKCYIG RKLFRDGSVS RELDWHGVIT VRRDHSQYVK DVYRKAVHRV
     FADCTMEQFK HTIFEQALTL MQRRVSYERL TKTSEVRNVG DCCTITLCKK TMSWMLGDYK
     VPQHSHHDIL YNTKRDALKT YYVSKLPAPA RLSVSLVDRG RPAIEGGRIE FLNIRISNPD
     DLPIEEISYF KEHGGIVDRL YYIKQIINPL TKVSEAVWKR SDTVIGAVTP ILNYDKVVRQ
     LDTMFN