ID   DPOL_ICHVA              Reviewed;        1512 AA.
AC   P28859; Q00157;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   23-FEB-2022, entry version 105.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=57/58;
OS   Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish
OS   herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Alloherpesviridae; Ictalurivirus.
OX   NCBI_TaxID=766178;
OH   NCBI_TaxID=7996; Ictaluridae (bullhead catfishes).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1727613; DOI=10.1016/0042-6822(92)90056-u;
RA   Davison A.J.;
RT   "Channel catfish virus: a new type of herpesvirus.";
RL   Virology 186:9-14(1992).
RN   [2]
RP   SEQUENCE REVISION.
RA   Davison A.J.;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; M75136; AAA88160.2; -; Genomic_DNA.
DR   PIR; D36792; DJBEI1.
DR   PIR; E36792; E36792.
DR   RefSeq; NP_041148.2; NC_001493.2.
DR   PRIDE; P28859; -.
DR   GeneID; 1488370; -.
DR   KEGG; vg:1488370; -.
DR   Proteomes; UP000007643; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase; Host nucleus;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1512
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000046521"
SQ   SEQUENCE   1512 AA;  172645 MW;  E05525322224CAFB CRC64;
     MDRNAVLYGV LEHRLPKWVE LSDDTDLEPF FFSSVRYITA GSEDAIMIQA LNLNTDEIVV
     FLVTNLNFMA LIPTVYIENP GIRQLIASTP ISYRSPITVF NGDLKKWMDC DLFVFGTMAA
     QKAFIKAGNS VLGSLGGNVY TYGDHVSNFD GNTPVLQNNL MCSHVYYTRY KTDVYAPWEF
     YYDQKRDQGY LMSLPAIIPR CKREGAFDIE TIVHENAMDQ DLNCQKFFKS EFRSMEESQV
     LIQRFREAGV TGLPPSPFVG ITQKLHEIVS ISLVVCNYHK TGPKKKEYYV YYNTKKMENP
     MEMIPVEHLH LDASRIKFEA CKNEFYMLLA FINRLRKSVN VLYVYNAQFD IQVIQQRLRY
     YAFKQRAPRC CKGHDDIPHE WGKALMEKWE AFLSVKPQLF KAQILMGQDI LKANYLKLLE
     GIGSVLAQAK STMAKMCTIK ERIDSYRKMK DTVQNFKSHG FGCDIIDMMY VCKRKEFEAK
     DGSLNTVAQL IIKKFKPHKA TPKIHKMDDI TYDKLDGYYR AGGTKIAECL IYNLIDSLLV
     IRIAKNLKPM EEYIYRQLAC YNIDTAAHTR GVMNFCGFIQ STKVVEVSRN KARLDAGIVM
     ATDYIRNSLF TPETIPRRGG FVMAPLTGLF FARPTQCFEL CLDFTSMYPS MMCDLNISPE
     TIVDSDKTNR VGDYMGYDWS KIDQGFEKFT LVLRVDRTDP ENPKLVRHTS DTSLSLKRYL
     RLRTEHKRAL KQSSGSVAEY HNRLQNEMKI CTNTHYGVSE HTCSLMITTQ GQHKIKLVNE
     FIKTLNRTGH SLFPNYGDTD STMLYHPSDE SETQLEDMVT LEDEMRAELR EYMLKKLSAE
     LVNRVKEKTK RTDTFVQSFL SDVETVLFDD MVEKLRLFSQ GEVIEPFKDG GTWWVVDPLT
     GIWMDCSTPF SSELICKLEY ENASSIGCHV AKKMYLSLVH ELNNGEIINT KIKKRGMTGF
     KSSRFGATES ITNDFMDLIF NGGALVKTGH LEALKPVTWA KLSAPADILH FSEPPVYENG
     ICLNMNSITL IPHRVTAVTR LPCPDIKGGE LVYVDLHEST SGKSSVLVLV LADGCALNHI
     FSSANVLHRE LSFETIAMFR AFFVGAGFLD PNSIVFYERI PRLKPEFLSK ITNYELFTGK
     KLKIPFVTLH KRKTTIQAIV KEDKKQIDYP EEWIKQDPAM AMFRRYPIDL RLERMIMDYF
     GSGLKCTLAT FTPPKYTVSG ERSRHSIVIK NHVDKHYLND NSKFLAHVVM DRAMPTTCYI
     HDDIDVKAMI QSVISRVVRM IQDTQVRLQE LSAAGNKLFH MFFNQLPPEM NNLDISFKYN
     PLVDHALQGQ KGVPGLQYGN PEQIYTDMIT EMTALLPRIG HMVEFMEWSQ ELSSSKTLCL
     LLPKIARDLN VPPLVTSLND DTGNAMLIAF AHKIYIATAM LHILHGENLE THDLGPQTGT
     GVVGEPPKHC TGAQLREWFI DLQKTLALDA PSTHCAGCAD FWLTHGSDPN FIEKMYRVNG
     GVFVRKIKKI CL