ID   DPOL_IIV3               Reviewed;        1141 AA.
AC   Q196U0;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   23-FEB-2022, entry version 75.
DE   RecName: Full=DNA polymerase 120R;
DE            EC=2.7.7.7;
GN   ORFNames=IIV3-120R;
OS   Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Betairidovirinae; Chloriridovirus.
OX   NCBI_TaxID=345201;
OH   NCBI_TaxID=7163; Aedes vexans (Inland floodwater mosquito) (Culex vexans).
OH   NCBI_TaxID=42431; Culex territans.
OH   NCBI_TaxID=332058; Culiseta annulata.
OH   NCBI_TaxID=310513; Ochlerotatus sollicitans (eastern saltmarsh mosquito).
OH   NCBI_TaxID=329105; Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus).
OH   NCBI_TaxID=7183; Psorophora ferox.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16912294; DOI=10.1128/jvi.00464-06;
RA   Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A.,
RA   Kutish G.F., Rock D.L.;
RT   "Genome of invertebrate iridescent virus type 3 (mosquito iridescent
RT   virus).";
RL   J. Virol. 80:8439-8449(2006).
CC   -!- FUNCTION: DNA-directed DNA polymerase involved in viral DNA
CC       replication.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; DQ643392; ABF82150.1; -; Genomic_DNA.
DR   RefSeq; YP_654692.1; NC_008187.1.
DR   SMR; Q196U0; -.
DR   GeneID; 4156331; -.
DR   KEGG; vg:4156331; -.
DR   Proteomes; UP000001358; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 2.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transferase;
KW   Viral DNA replication.
FT   CHAIN           1..1141
FT                   /note="DNA polymerase 120R"
FT                   /id="PRO_0000376942"
SQ   SEQUENCE   1141 AA;  132237 MW;  F346243576D68911 CRC64;
     MDKPSTKIVN DYTHFYAYSW HVDEESVDET FIRVYGLDEA NENVCVSVNG FRQFVWVELP
     SFIDWSLSHN VDRVVRYFEQ TWPNVGVQFK MYRKLYGANL KQSRSNGEYV HKKFPFLQCS
     SMSWKMLKFT LPTALKTPQR IMGLGSIKFR VHGQDACPRL QLTSKYNLPT AGWIQFKGIE
     ILDQDVKFSQ SCREFMVDLS DKNWGKPSTM ICRSDKTTVP RPLILSFDLE VNSEEVVTMP
     KATKPGDVVF QISCIFNRLG GVENEVERYL LSLGNPTEQI VGATILRYST EKKLLMGFRD
     LVNEKNPNVI TGYNIFNFDI PYLMDRTVYK SIFVEWAQQG FAKNRPGIPR EIRWSSSAYK
     NQEFKYLDCE GRLYIDLLPV VQRDFKLNDY KLKTVSTFFI GETKDDLDPT SIFRCYREGT
     RDDSPKASHF MSICGKYCMQ DSMLVYKLFE KLNVWYGLSE MAVVCNVPMI TLFTKGQQIK
     VYSQLYKYCL AAKIIPEKDG YIVAENERYV GAHVFTPKPG LYENVIPLDF SSLYPSLMIA
     YNIDYSTCAF DASIPDQLCH IMEWEDHIGC AHDPKVVEKE RLTQLINTLK NKEEVSRMRK
     ERSEITKSLS KNVMCEKRKY RFLKSTTEDG RFKGVLPTIV QNMLDARKET RAEMGRLKKR
     LGTAVGEEAT HLQTQIAILN QRQLAYKVSA NSMYGITGVK AGMLPFMPVA MSITFMGRTN
     IARVAQLLQT QYQGELVYGD TDSNYVSFNH KNMSMSELWD YAIRVADEIS QQFPPPIKLE
     FEEAIYSKFL ILTKKRYLYQ TALRDGTIKK EIGKRGVVLN RRDNSGFIRK IYQNMVDSIF
     NHVAGEGRDL KSVVLDVVTA DICALFNHQF PVDDFVITKS TGNYGDLQPE NFVNEKGVPR
     AMLGQYNVPC LTSQVREEER IETEEQEQNW YLDKLPAHIQ LLEKIRRRGQ MKNEGGRLEY
     VIVETNSLKD KQSTKIETLP YYTKNRGILK LDYLYYLHRC INPLDQILKV VFDLDDFVKR
     QYKAREAKKK VTLELGELFR PNFIIEKSQL QLVRARADEV YRLVYGTAAD CRAQLGELGP
     DWCVRAKFEY VPLVDDPYRY FQQKYGATGS LKTKFDFEGR DIRLNNQPES KLVSTLKREF
     K