ID   DPOL_METVO              Reviewed;         824 AA.
AC   P52025;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=pol;
OS   Methanococcus voltae.
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=2188;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7929013; DOI=10.1128/jb.176.20.6402-6403.1994;
RA   Konisky J., Paule S.M., Carinato M.E., Kansy J.W.;
RT   "The DNA polymerase gene from the methanogenic archaeon Methanococcus
RT   voltae.";
RL   J. Bacteriol. 176:6402-6403(1994).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}.
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DR   EMBL; L33366; AAA72443.1; -; Genomic_DNA.
DR   AlphaFoldDB; P52025; -.
DR   SMR; P52025; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; DNA-directed DNA polymerase;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..824
FT                   /note="DNA polymerase"
FT                   /id="PRO_0000046478"
SQ   SEQUENCE   824 AA;  96755 MW;  094A630D8C1514FC CRC64;
     MDLDYNSKDL CIDMYYKNCG LKKPEINLQK ECEFKPYFYV DTSEPKEIYD YLDGLNQEID
     LKKLEPEFEN NTSLKVQDLI TNIEIIEKIV YSDYILNGKD ISEVSDFKNK KERKICKVYV
     KYPNHVKIIR EYFKEFGKSY EFDIPFLRRY MIDQDIVPSA KYSEDNKIDN SIPELNCIAF
     DMELYCKKEP NAKKDPIIMV NLFSKDYQKV ITYKKFENSE YNGCVDYVKD EKELIQKTIE
     ILKQYDVIYT YNGDNFDFPY LKKRANIYEI ELDFDNASNS QQPQIIKISK GGINRKSKIP
     GIIHIDLYPI ARKLLNLTKY KLENVVQELF KINKEAVDYG DIPKMWETED TTLLRYAYED
     ALYTYKMGNY FLPLEIMFSR IVNQPLYDTS RMNSSQMVEF LLLKRSFEQN MISPNRPSSS
     SYRERAKFSY EGGYVREPLK GIQEDIVSLD FMSLYPSILI SHNISPETVI YEEKERENME
     LGIIPKTLNE LLSRRKHIKM LLKDKIQKNE FDEEYSRLEH EQKSIKVLAN SHYGYLAFPM
     ARWYSDKCAE MVTGLGRKYI QETIEKAEEF GFKVIYADTD GFYAKWDYDK LQKGKKEEND
     KSDKLSNLPK LSKEELIILT KKFLKGINEE LPEGMELEFE GHFKRGLFVT KKKYALIEDD
     GHIVVKGLEV VRRDWSNIAK DTQQAVIRAL LEDGDVNLAK KIIKNTIDNL KKGNIDKNDL
     LIHTQLTKNI EEYKSTAPHI EVAKKIKQRG DSVRVGDVIS YIIVKGSRSI SERAELLEYA
     GDYDINYYID NQVLPPVIRI MESLGISEDE LKNSGKQFKL DQFM